tag:blogger.com,1999:blog-8550919611653842066.post2089263868468570731..comments2023-10-24T19:10:17.771-07:00Comments on The High-fat Hep C Diet: Do moderate ketone levels from low carb protect against symptomatic hypoglycemia in type 1 diabetes? A relevant case study.Unknownnoreply@blogger.comBlogger5125tag:blogger.com,1999:blog-8550919611653842066.post-53214187980341279702015-11-01T23:47:23.946-08:002015-11-01T23:47:23.946-08:00Medium-Chain Fatty Acids Improve Cognitive Functio...Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia<br /><br />Hypoglycemia impaired cognitive performance in tests of verbal memory, digit symbol coding, digit span backwards, and map searching. Ingestion of medium-chain triglycerides reversed these effects. Medium-chain triglycerides also produced higher free fatty acids and β-hydroxybutyrate levels compared with placebo. However, the increase in catecholamines and symptoms during hypoglycemia was not altered. In hippocampal slices β-hydroxybutyrate supported synaptic transmission under low-glucose conditions, whereas octanoate could not. Nevertheless, octanoate improved the rate of recovery of synaptic function upon restoration of control glucose concentrations.<br /><br />CONCLUSIONS<br /><br />Medium-chain triglyceride ingestion improves cognition without adversely affecting adrenergic or symptomatic responses to hypoglycemia in intensively treated type 1 diabetic subjects. Medium-chain triglycerides offer the therapeutic advantage of preserving brain function under hypoglycemic conditions without causing deleterious hyperglycemia.<br /><br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671041/Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-14840429529824368002015-10-07T19:19:16.291-07:002015-10-07T19:19:16.291-07:00They didn't say whether the KD included MCTs. ...They didn't say whether the KD included MCTs. It's safe to assume it did and that this accounts for the ketones showing at low ketogenic ratios. <br />Substrate availability can over-ride hormonal controls on metabolism, this is the case with hyperglycaemia which produces insulin-independent effects.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-7053253471313225992015-10-07T18:12:11.597-07:002015-10-07T18:12:11.597-07:00Yes a very interesting paper, I doubt it would be ...Yes a very interesting paper, I doubt it would be possible to get permission to do it these days!<br /><br />In prolonged fasting subjects have very high growth hormone levels which is lipolytic.<br /><br />Even though the drop in FFA was high in fasting + insulin the level of FFA was still reasonable.<br />Beta oxidation derived Acetyl-CoA exceeding the capacity of the citric acid cycle especially with depletion of oxaloacetate due to up regulation of gluconeogenic pathway possible.<br /><br />Even under relatively high glucose/insulin condition consuming ethanol/MCT/SCFA will promote excess acetyl-CoA that can spill over to ketone production.johnnyvhttps://www.blogger.com/profile/08815010039118878013noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-79073256796160377452015-10-07T00:33:11.604-07:002015-10-07T00:33:11.604-07:00Thank you John, that's brilliant.
I expect in...Thank you John, that's brilliant. <br />I expect insulin's ability to suppress ketogenesis depends on how much glucose is available to supply oxaloacetate. <br />And that insulin's ability to store fat depends on how much glucose is available to supply glycogen. DGAT2 in adipocytes and liver, a rate-limiting step for triglyceride synthesis, is controlled by glucose, not insulin.<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/12413942Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-10147906199084473622015-10-06T16:10:00.828-07:002015-10-06T16:10:00.828-07:00Resistance to Symptomatic Insulin Reactions after ...Resistance to Symptomatic Insulin Reactions after Fasting<br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC332976/?tool=pmcentrezjohnnyvhttps://www.blogger.com/profile/08815010039118878013noreply@blogger.com