tag:blogger.com,1999:blog-8550919611653842066.post3028937132076550505..comments2023-10-24T19:10:17.771-07:00Comments on The High-fat Hep C Diet: A catch-all round-up grab-bag of stuffUnknownnoreply@blogger.comBlogger14125tag:blogger.com,1999:blog-8550919611653842066.post-46194218525287512132013-09-09T17:25:05.057-07:002013-09-09T17:25:05.057-07:00See figure 3 here - secondary bile acids prevent a...See figure 3 here - secondary bile acids prevent atherosclerosis?<br />http://www.nature.com/nature/journal/v489/n7415/full/nature11552.html<br /><br />Also http://www.hindawi.com/journals/jdr/2011/853501/Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-81954518552084186372013-09-03T20:07:40.860-07:002013-09-03T20:07:40.860-07:00I found this:
http://www.ncbi.nlm.nih.gov/pubmed/...I found this: <br />http://www.ncbi.nlm.nih.gov/pubmed/10494717<br />It has been suggested that infection with hepatitis C virus may be associated with the development of lichen planus and that geographical area may be an important factor affecting the relative risk.<br /><br />but not in NW England.<br />Is this because in colder regions, the effect of vit D deficiency is more important than any HCV association?Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-86805102985267926132013-09-02T19:46:48.280-07:002013-09-02T19:46:48.280-07:00P.S. the precursor they used to create inflammatio...P.S. the precursor they used to create inflammation in the paper, 7-DHC, is converted to vitamin D3 under UVB light. Do you get much sun, and what happens when you do? It may be that your skin is trying to make vitamin D but not getting enough sun.<br />Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-9478011879737283512013-09-02T19:37:41.580-07:002013-09-02T19:37:41.580-07:00That's very interesting and may have implicati...That's very interesting and may have implications for Hep C where chlesterol completion is also being blocked.<br />At first sight this looks like something that probiotics might help, because of the TLR and interferon connection. There is probably a connection between what's happening with the gut and with the skin. There are reports of improving LP with gluten-free and paleo diets. Have a look at this example<br />http://www.thepaleomom.com/2012/04/modifying-paleo-to-treat-psoriasis.html<br /><br />I had mild psoriasis clear up when I supplemented selenium, zinc, and fish oil. Not the same thing, but the oils and antioxidants in the skin will be important, and the gut; I would probably try a rhamnosus plus bifidus probiotic, and maybe aloe vera juice, or spirulina, but I'd add spirulina separately just in case, but these are the things that helped my gut most. And vitamin D3.<br />That and a low-carb diet without grains, legumes, sugar and vege seed oils.<br />You don't say if you've tried any supplements or eat any special way.<br /><br />Generally the best advice about the gut is in Chris Kresser's Healthy Skeptic blog. He has an entry on the gut-skin axis here: http://chriskresser.com/the-gut-skin-connection-how-altered-gut-function-affects-the-skinPuddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-70159202032462736892013-09-01T07:02:15.641-07:002013-09-01T07:02:15.641-07:00Great blog Mr Henderson! I have a rare scalp/hair ...Great blog Mr Henderson! I have a rare scalp/hair disorder by the name Lichen planopilrais(lichen planus on the scalp) and the latest pub med research linking my disorder to changes in the cholesterol biosynthetic pathway in the skin.<br /><br />http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0038449<br /><br />Do you think there is a connection with my body not able to take up cholesterol and by so the cholesterol pathway changes in my skin? <br /><br />I can add that I also have serious digestive problems and lsot 9kg in 2 months.<br />Joakimhttps://www.blogger.com/profile/10293473961476591129noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-71151188963131302422013-09-01T07:01:51.442-07:002013-09-01T07:01:51.442-07:00This comment has been removed by a blog administrator.Joakimhttps://www.blogger.com/profile/10293473961476591129noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-34191307031887694792013-08-25T14:56:16.071-07:002013-08-25T14:56:16.071-07:00Interesting link from Peter D about omega-6 EFAs f...Interesting link from Peter D about omega-6 EFAs fueling cancer growth - specifically hepatoma.<br />http://www.ncbi.nlm.nih.gov/pubmed/3130186<br /><br />Perfusion of tumors with normolipemic blood containing added linoleic and arachidonic acids increased [3H]thymidine incorporation. Blood mixtures containing palmitic, stearic, and oleic acids were inactive.<br /><br />The whole of Peter's discussion is here: http://high-fat-nutrition.blogspot.co.nz/2013/08/starvation-and-cancer-growth-sauer-vs.htmlPuddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-9411946596977676672013-08-24T15:24:56.316-07:002013-08-24T15:24:56.316-07:00My insurance (in the USA) covers these tests - I s...My insurance (in the USA) covers these tests - I should be getting them next month when I see my doctor. If I get them I will let you know the results.Anonymoushttps://www.blogger.com/profile/10709553155869979806noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-35240671812149794532013-08-24T15:05:32.079-07:002013-08-24T15:05:32.079-07:00Thanks Charles, interesting stuff. I would be very...Thanks Charles, interesting stuff. I would be very surprised if ANY doctor prescribing statins in NZ runs genetic testing to determine safety of what they are doing. This is telling us that safe use of statins, if such a thing exists, is a prerogative of the very rich.<br />Many things we use are produced by fermentation and I would expect that allergic reactions are rare.<br />If statins promote health, then statin users should be fitter and happier than they are. Subjective effects, QOL, are important factors. I think these minor side-effects, breathlessness, diarrhea, forgetfulness, are sub-clinical manifestations of the same processes that cause more lethal side-effects.<br />Thanks for the links. If statins are prescribed on the basis of total C levels, and these are misleading guides to cholesterol synthesis and CVD risks, then it is little wonder the benefits in general use are so nugatory.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-43686476599492773812013-08-24T07:11:05.781-07:002013-08-24T07:11:05.781-07:00http://www.nejm.org/doi/full/10.1056/NEJMoa0801936...http://www.nejm.org/doi/full/10.1056/NEJMoa0801936#t=articleMethods<br /><br />We provide compelling evidence that at least one common variant in the SLCO1B1 gene substantially alters the risk of simvastatin-induced myopathy. Among patients taking 20 to 40 mg of simvastatin daily (or standard doses of other statins), the incidence of myopathy is typically only about 1 per 10,000 patients per year,4 and the effect of these gene variants on the absolute risk of myopathy is likely to be small (as indicated by our results among participants in the Heart Protection Study). In contrast, the risk of myopathy may be substantially increased in patients who take 80 mg of simvastatin daily (and some other high-dose statin regimens), as well as in those who are also receiving certain other drugs2-4 (e.g., cyclosporine and, as we found in SEARCH, amiodarone11). Hence, the use of those drugs in subjects who are taking such high doses of statins and who have the C allele of the rs4149056 polymorphism may produce particularly high risks of myopathy (Figure 2).Anonymoushttps://www.blogger.com/profile/10709553155869979806noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-43749586043413049812013-08-24T07:08:50.168-07:002013-08-24T07:08:50.168-07:00Then there is the question of whether one is a hig...Then there is the question of whether one is a high producer/absorber of cholesterol - markers of cholesterol production (lathosterol and desmosterol) and absorption (beta-sitosterol, campesterol, and cholestanol).<br /><br />http://jn.nutrition.org/content/141/10/1791.full<br /><br />Cholesterol synthesis/absorption status was not markedly altered by diet, but the decrease in plasma LDL-C due to the Mediterranean-type diet occurred only in low absorbers of cholesterol. This should be considered during further dietary interventions. <br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724787/<br /><br />These data suggest that impaired cholesterol homeostasis, reflected by lower synthesis and higher absorption marker concentrations, are highly significant independent predictors of prevalent CVD in this study population. <br />SO - it's not as cut and dried as one would rthink.<br /> <br />Anonymoushttps://www.blogger.com/profile/10709553155869979806noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-80215819625829263652013-08-24T07:06:00.832-07:002013-08-24T07:06:00.832-07:00On Dr Briffa's blog you said "I have neve...On Dr Briffa's blog you said "I have never seen anyone who feels better on statins. People tend to be breathless and tired, if they do not develop gut and muscle problems. I’m opposed to taking any drug that doesn’t make you happier and healthier than you were before you started. Diarrhea and ulcerative colitis are statin side effects that are under-reported because attributed to other causes, whereas myositis is unusual in other contexts so easier to diagnose. And then there are the neurological syndromes.<br />In theory one could get the same benefits by supplementing taurine, magnesium and fish oil, or by restricting dietary cholesterol, refined carbohydrate and omega-6 oils."<br /><br />Have you considered that people may be taking the wrong statin?<br /><br />For example - 3 of the statins currently available are made via fermentation from mold - if one has an allergy to mold that would cause problems.<br /><br />There are also genetics involved.<br /><br />Three SLCO1B1 genotypes have been identified and classified in terms of their effect on statin metabolism in the liver—normal (T/T), heterozygote (T/C), and homozygote (C/C): <br />The T/T genotype (valine/valine) is classified as normal. These patients have a normal ability to metabolize statins (about 70% of the population). Standard doses of statins are recommended for LDL-C lowering and CVD risk reduction. <br />The T/C genotype (valine/alanine) is classified as an intermediate metabolizer. These patients have a decreased ability to metabolize statins (about 26% of the population). They are at a four-fold increased risk for developing statin induced myopathy. They also achieve less LDL-C lowering from the statin that they receive. <br />The C/C genotype (alanine/alanine) is classified as a poor metabolizer. These patients have a significantly decreased ability to metabolize statins (up to 5% of the population). They are at a seventeen-fold increased risk of developing myopathy on statin therapy. <br /><br />Anonymoushttps://www.blogger.com/profile/10709553155869979806noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-83424277802288671412013-08-22T18:56:16.394-07:002013-08-22T18:56:16.394-07:00Yes, there's some evidence that HBV is less li...Yes, there's some evidence that HBV is less likely to become chronic in persons with adequate selenium status, and optimal selenium protects against hepatocellular cancer.<br />I figure that the drop in liver enzymes in the Bucharest study could be entirely due to the extra antioxidants in the diet. These enzyme scores were not very high to begin with. And WHY is this called a Liver Function Test? GGT, AST, ALT are hepatocyte damage measurements that say NOTHING about liver function. If anything, they indicate the influence of a likely threat to liver function at some indeterminate future date.<br />Bilirubin, albumin, platelets, and whether triglycerides are diet-appropriate - those are markers of liver FUNCTION.<br /><br />Qualified people - R D Feinman, for example - and people who think they are qualified, like Carbsane, don't supply link references. I might stop doing it except for novelties, and of course music. Googling stuff oneself is easy and satisfying and anyone can learn to do it.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-16145018022782931662013-08-22T06:37:14.696-07:002013-08-22T06:37:14.696-07:00Another benefit to emphasizing food quality for he...Another benefit to emphasizing food quality for hep c is that micronutrients and overall health relates to immunity and ability to resist viral syndromes; other than the benefits of better quality fats with regard to potential hepatic complications you have the factor of preventing viral replication in the first place by , say, eating healthful foods and being replete of nutrients like vitamin D3.<br /><br />My writing is largely unreferenced I know, will never be a professional blogger but if one fact checks/verifies my arguments you shall find nary a quackery...and if so, I apologize ;)<br /><br />These days I have almost zero signs of any digestive / gastric upset. So amazing! Quality of life way better! Not sure how much is owed to D3 too but still using probiotic and do not intend to stop.ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.com