tag:blogger.com,1999:blog-8550919611653842066.post4830655697616033068..comments2023-10-24T19:10:17.771-07:00Comments on The High-fat Hep C Diet: On Participating in a Phase III Trial of Sofosbuvir and GS-5816 for Hepatitis CUnknownnoreply@blogger.comBlogger39125tag:blogger.com,1999:blog-8550919611653842066.post-27397921303035213572017-02-26T16:37:39.137-08:002017-02-26T16:37:39.137-08:00Yes, I have regular follow-up tests with the Clini...Yes, I have regular follow-up tests with the Clinical Trials people, and it's still clear. My last liver function test had ALT and AST at 15 which would be ideal for a non-drinker with no Hep C or NAFLD.<br />This drug combo is called Epclusa now and marketed for genotype 3.<br />I'm still trying to get my hypothesis about Hep C and low carb published and tested.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-35778442933102711962017-02-22T20:27:27.709-08:002017-02-22T20:27:27.709-08:00Are you still clear of the virus? This is such an ...Are you still clear of the virus? This is such an amazing story.Ninahttps://www.blogger.com/profile/03897002455039722779noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-57865027153046876352016-05-25T21:59:17.287-07:002016-05-25T21:59:17.287-07:00Zinc is excellent for cramps related to liver dise...Zinc is excellent for cramps related to liver disease. Mag Phos is not a good magnesium, Magnesium citrate is best, amino acid chelate (= Mg aspartate) is good; zinc gluconate is the best zinc form to supplement. I was taking both these during my Tx and I think zinc especially lowered enzymes and helped scarring resolve quickly during Tx.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-9131369629304670192016-05-24T00:15:52.161-07:002016-05-24T00:15:52.161-07:00Thanks George - I will start taking it with nuts....Thanks George - I will start taking it with nuts. I'm noticing eating high fats or rich food - (e.g. today the coconut cream in pumpkin soup) - I feel slightly nauseas - and yes I do have fatigue. Im also taking mag phos but still having lots of cramp at night so might look at the zinc. jazahttps://www.blogger.com/profile/01001842156358575759noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-18613810916063422042016-05-23T18:35:39.847-07:002016-05-23T18:35:39.847-07:00Sorry to take so long - yes all DAAs as far as I k...Sorry to take so long - yes all DAAs as far as I know should be taken with fatty food. This may be more important with generics as they are not formulated to disperse so well (though data I've seen suggests there is probably little difference)Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-13541288888255746782016-05-03T18:19:28.004-07:002016-05-03T18:19:28.004-07:00Just looking here in case someone else has the gen...Just looking here in case someone else has the generic drugs for treatment via Greg Jefferies from India.<br />Wanting to know about taking them with food or high fat as I have previously read.<br />Thanks.jazahttps://www.blogger.com/profile/01001842156358575759noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-43322836300296044272015-10-04T00:21:37.517-07:002015-10-04T00:21:37.517-07:00This comment has been removed by the author.Anonymoushttps://www.blogger.com/profile/12470171317551607971noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-62223425755433765942015-10-03T14:13:31.421-07:002015-10-03T14:13:31.421-07:00Hi Sarah,
I think vit C is useful, but just as par...Hi Sarah,<br />I think vit C is useful, but just as part of an antioxidant regime. It's worth trying a higher dose at first to see what happens but this can cause problems (diarrhea and UTIs) if you overdo it. NAC is cheaper than glutathione and probably just as effective. Take it with a mixed-antioxidant supplement. l-carnitine is good too. I think zinc gluconate was very helpful to me at 30mg (also stopped leg cramps).<br />Definitely, take probiotics - this will really help.<br /><br />This study used a low carb diet to reduce fatty liver, which sounds like part of your problem (especially if you have geno 3, but also with other genotypes). Reversing fatty liver with low carb doesn't need weightloss.<br /><br /><br /><a href="http://www.diabesityinpractice.co.uk/media/content/_master/4311/files/pdf/dip4-3-102-8.pdf" rel="nofollow">http://www.diabesityinpractice.co.uk/media/content/_master/4311/files/pdf/dip4-3-102-8.pdf</a><br /><br />Foods I think are especially helpful are coconut oil and butter or ghee. Olive oil is OK too. Avoid other vegetable oils - get all the PUFA you need from a little nuts, seeds and fish (actually, eat a few brazil nuts every day for the selenium, that'll take care of your PUFA requirements too). Eat lots of green veges - whatever you can get, I like okra, spinach, leek, methi, broccoli - cooked in coconut oil or butter. Eat some unprocessed red and white meat, only eat cheese if you tolerate it, and above all -<br />avoid sugar, as sugar, honey, agave, coconut sugar, dried fruit, fruit juice - whatever. Don't eat this stuff unless or until you can use it very occasionally in tiny amounts.<br /><br />Good luck Sarah, please let me know how you get on.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-54098644513184061622015-10-01T12:23:27.436-07:002015-10-01T12:23:27.436-07:00This comment has been removed by the author.Anonymoushttps://www.blogger.com/profile/12470171317551607971noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-59535569760849782062015-10-01T12:22:34.772-07:002015-10-01T12:22:34.772-07:00This comment has been removed by the author.Anonymoushttps://www.blogger.com/profile/12470171317551607971noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-73789904639832946912015-04-14T20:07:59.180-07:002015-04-14T20:07:59.180-07:00Here, I think is the trial report, and I'm the...Here, I think is the trial report, and I'm the nut in the Sof + 25mg GS-5816 -<br />arm with a respiratory infection.<br />Pretty good results here.<br /><br />http://www.natap.org/2014/AASLD/AASLD_13.htmPuddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-745917957837556772015-01-05T05:31:06.820-08:002015-01-05T05:31:06.820-08:00After reading this it is the first time I am consi...After reading this it is the first time I am considering going back to the Hep C doctor. It's been a while and know I am in bad shape.shendhttps://www.blogger.com/profile/07280178607773360490noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-10503609373462009862014-10-18T19:34:23.969-07:002014-10-18T19:34:23.969-07:00Hi Fran,
This is the first report of this side eff...Hi Fran,<br />This is the first report of this side effect I've seen with this combination; nausea, indigestion are fairly common, photosensitivity is possible. I definitely noticed something for the first month.<br />I can't think of much - massage and/or yoga would probably be the best thing. I found that zinc gluconate really helped with leg cramps. Maybe pyridoxine would help (about 10mg) if you don't take it already, indeed a B complex vitamin or multivitamin, doesn't have to be high dose, maybe better if it's not.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-54716593018553627412014-10-15T13:44:09.200-07:002014-10-15T13:44:09.200-07:00Hi George, Im Fran. I am Geno type 3. 4 weeks ago ...Hi George, Im Fran. I am Geno type 3. 4 weeks ago I began the Phase 3 trial for the sofo/GS5816 combo. one pill. I enjoyed your blog info. Im believing for SVR12 also. My drug time is 12 weeks with Dec 19th being the last dose for me. I do have to admit, I must be an anomaly. I have had various side effects. The most noticeable are constant leg twitches, I am on a potass and mag supplement daily and get checked regularly. I can, when my potass is low, do have twitches and irregular heart beats. But, I have regular blood draws and each time my potass and mag are good. The twitches are prominent. I also experience flickerings all over my body of the muscles. Spasms also and after a tough day of these sides I am sore and achy the next day. I have a had so much blood drawn to keep checking the levels, that i feel like a pin cushion. All my labs are good and Trial Dr. said there is nothing indicating that there is any damage or problems with my kidneys, etc. So I am chalking it up to side effects. A friend of mine who is an advocate for HepC said it is possibly neurological and will pass after the treatment is finished. I also have wanted to quit quite a few times. These sides did cause a panic attack and now if necessary I can take xanax. IF necessary. Im not big on taking drugs at all. My body always responds weirdly to meds so I avoid them as often as possible. I did get headaches, fatigue too. I am hoping that these 12 weeks will be worth it. I appreciate what you wrote. It gives me hope. I think I can make it through this for the reward. Oh I am on the 400/100 mg dose. Is there anything you are aware of that could help with the twitches...etc? Vitamins? I will hang tough though. I want this so badly. I am 56 and have fibrosis2. I wont know how to find your answer. Because someone posted this on my Hep C support group on FB. Could you "friend" me on FB? my name is Frannie Ford. my picture is a lady in a white sundress facing a mountain with my arms up in the air. Thank you. And Thank you for your post on this subject. Gives me understanding and hope!Franhttps://www.blogger.com/profile/05418714688787999328noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-14479531576958768672014-06-17T16:35:21.684-07:002014-06-17T16:35:21.684-07:00http://www.aidsmap.com/Sofosbuvir-new-GS-5816-NS5A...http://www.aidsmap.com/Sofosbuvir-new-GS-5816-NS5A-inhibitor-is-effective-against-hepatitis-C-genotypes-1-6/page/2847422/<br /><br />This study included 154 previously untreated hepatitis C patients without liver cirrhosis. About 60% were men, most were white and the mean age was approximately 50 years. Nearly 30% had HCV subtype 1a, which is considered most difficult to treat. In addition, 7% had HCV subtype 1b, 14% had genotype 2, 35% had genotype 3, 9% had genotype 4, a single individual had genotype 5 and 6% had genotype 6. About one-third had the favourable IL28B CC gene variant associated with interferon responsiveness.<br /><br />Participants in this open-label study were randomly assigned to receive 400mg once-daily sofosbuvir plus either 25mg or 100mg once-daily GS-5816 for 12 weeks. They were followed after finishing therapy to determine sustained virological response, or continued undetectable HCV viral load at 12 weeks post-treatment (SVR12), which is considered a cure.<br /><br />SVR12 rates for people with genotype 1 were 96% using the 25mg GS-5816 dose and 100% using the 100mg dose. For people with genotype 2, the corresponding rates were 91% and 100%, respectively, while the cure rates for genotype 3 were 93% in both dose arms.<br /><br />Turning to the less common genotypes – where the numbers were too small to draw meaningful conclusions – genotype 4 SVR12 rates were 100% and 86%, respectively, in the 25mg and 100mg dose groups. The single genotype 5 patient and all genotype 6 patients in both dose arms were cured. Across all genotypes, overall SVR12 rates were 95% using the 25mg dose and 96% using the 100mg dose.<br /><br />Looking at the patients who did not achieve SVR12, three people relapsed after completing treatment: one person with genotype 1 taking 25mg GS-5816, one person with genotype 3 taking 25mg and one person with genotype 3 taking 100mg. In addition, one person with genotype 3 was a non-responder during treatment, one person with genotype 2 died during follow-up and one person with genotype 3 was found to be re-infected.<br /><br />Genetic sequencing revealed that about one-quarter of people with genotype 1-3 had pre-existing resistance-associated NS5A viral variants. Among them, virological failure was more likely using the lower GS-5816 dose (5% vs 2%). However, most people with pre-existing variants were cured.<br /><br />Treatment with sofosbuvir and GS-5816 was generally safe and well-tolerated. Four people had serious adverse events, three of them in the 25mg dose arms. However, no one discontinued for this reason. The most common side-effects reported by at least 10% of participants were fatigue, headache, nausea and constipation. No one developed anaemia, a side-effect often seen with ribavirin.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-62793660038063053062014-05-02T06:02:28.108-07:002014-05-02T06:02:28.108-07:00Wonderful news George, i am like you, i have been ...Wonderful news George, i am like you, i have been waiting for the right treamtent since 1995 and doing alternative treatments... waiting for led/sof in the fall to be approved peace, connieAnonymoushttps://www.blogger.com/profile/06444758783131068742noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-56202810569516275732014-04-18T20:05:52.580-07:002014-04-18T20:05:52.580-07:00Silvia, I know how long you've been looking fo...Silvia, I know how long you've been looking for that - well done.<br />All scans were done when fasting. <br />Even if the first scan's 7.4 was inaccurate, the one a year or two before that was 6.4, and I had one done more recently (in week EOT+12) and it was 5.3, confirming the earlier score was accurate.<br />I blame zinc 30mg/day, plus clearing the virus.<br /><br />shtove :)<br />Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-37065827663481661772014-04-18T19:56:36.513-07:002014-04-18T19:56:36.513-07:00Michael, I'm sure that within a year or two th...Michael, I'm sure that within a year or two there will be several copy-cat drug combos competing with Solvaldi, and prices will tumble.<br />Think of the benzodiazepines; first Librium, then Valium, after that the deluge of similar drugs with essentially similar effects (I can name about 20 of them, having taken every single on of them).<br />The high price will only last as long as Gilead have the advantage of being alone in the field.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-73484593623621691902014-04-15T21:23:28.876-07:002014-04-15T21:23:28.876-07:00Your good news made me cry. I'm very happy fo...Your good news made me cry. I'm very happy for you. <br /><br />I have good news of my own. I finally found a study that proved hepatitis transmission to MILITARY RECRUITS from a jetgun used to vaccinate them. Plus a beautiful paper that proves that not only is dose and route important in the kind of reaction an injection creates but also the SPEED at which it is given.Silvia Pricehttps://www.blogger.com/profile/09985995287230098038noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-11597920829011019062014-04-14T09:12:23.573-07:002014-04-14T09:12:23.573-07:00George:
Love the blog, but don't have your em...George:<br /><br />Love the blog, but don't have your email, so I don't have another way to send the following item to you. I assume you moderate comments. In general, I'm sure you are interested in CHC drugs. In particular, Sovaldi. It's stratospheric price has attracted attention here in the U.S.<br /><br />http://www.sfgate.com/health/article/Cost-of-Gilead-s-hepatitis-C-pill-Sovaldi-spurs-5398315.php<br /> <br /><br /><br /><br />Mike Sheldrickhttps://www.blogger.com/profile/15928956550862592493noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-86315722964724791992014-04-14T05:24:48.224-07:002014-04-14T05:24:48.224-07:00http://www.medicalnewstoday.com/articles/275484.ph...http://www.medicalnewstoday.com/articles/275484.php <br />Currently, doctors treating hepatitis C patients with cirrhosis (liver scarring) can only offer treatments that rely on the drug interferon, which unfortunately, only works for less than half of patients. Now, a new study found that an interferon-free combination of drugs was safe, well tolerated and cured over 90% of 380 trial patients with liver cirrhosis in 12 weeks. <br /><br />Apparently the combo of 4 drugs had very encouraging results. annleehttps://www.blogger.com/profile/17666381399321975755noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-50544237090440342842014-04-13T15:50:58.843-07:002014-04-13T15:50:58.843-07:00So no sign of the virus?
Help us out with some sm...So no sign of the virus?<br /><br />Help us out with some smilies.shtovehttps://www.blogger.com/profile/16109559722715781557noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-70115722995177183212014-04-13T14:19:55.985-07:002014-04-13T14:19:55.985-07:00It's official; SVR12.It's official; SVR12.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-76791982299649380862014-04-11T19:52:59.114-07:002014-04-11T19:52:59.114-07:00To lissjeanrosa:
Taking Metformin would increase y...To lissjeanrosa:<br />Taking Metformin would increase your chances of SVR.Silvia Pricehttps://www.blogger.com/profile/09985995287230098038noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-66655415460734838282014-04-11T19:48:47.446-07:002014-04-11T19:48:47.446-07:00I don't think that cirrhosis can regress that ...I don't think that cirrhosis can regress that quickly. Did you have both Fibroscans while you were fasting? Because having a meal before the fibroscan causes some liver stiffness.Silvia Pricehttps://www.blogger.com/profile/09985995287230098038noreply@blogger.com