tag:blogger.com,1999:blog-8550919611653842066.post5368732075965412891..comments2023-10-24T19:10:17.771-07:00Comments on The High-fat Hep C Diet: Linoleic Acid (Omega 6 PUFA) promotes hepatic cholesterol accumulation - Bigtime.Unknownnoreply@blogger.comBlogger10125tag:blogger.com,1999:blog-8550919611653842066.post-79435314052821185252013-08-20T15:23:38.775-07:002013-08-20T15:23:38.775-07:00To be exact, most HCV plus diet epidemiology paper...To be exact, most HCV plus diet epidemiology papers seem to use a formula like this; comparing persons with intake (total or calories %) below or at the RDI for any given macronutrient against persons with intake above the RDI.<br />This kind of assumes that the RDI is set at the level most relevant for its effects on hep C...Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-65706584719006981522013-08-19T21:02:07.483-07:002013-08-19T21:02:07.483-07:00It looks interesting, especially if it brings in f...It looks interesting, especially if it brings in fat, cholesterol and so on. Should improve sales of aspartame.<br />In HCV epidemiology (such as it is) fructose has only weak association with fibrosis (OR 1.147) dwarfed by effect of PUFA (OR 2.7 steatosis - alcohol is only 2.4!) and total carbohydrate (OR 2.9 fibrosis).<br />But science is weak, only uses high/low differential where quartiles or quintiles would give much more clarity.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-91195790251510129032013-08-19T05:29:25.667-07:002013-08-19T05:29:25.667-07:00Another good post, George. This following link had...Another good post, George. This following link had a bit of an ANZAC feel to it, so thought I'd share: <br /><br />http://gameauland.com/that-sugar-film-teaser/<br /><br />Of course there appears to be some obvious flaws in it, but I guess it has promise. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-70912973751127382652013-08-17T04:44:06.946-07:002013-08-17T04:44:06.946-07:00There is a discrepancy in the regulation of HMG-Co...There is a discrepancy in the regulation of HMG-CoA - <br />reductase and LDL receptor activities in liver from animals fed cholesterol with linoleic acid. In spite of a high <br />content of hepatic cholesterol and obvious suppression of <br />hepatic HMG-CoA reductase activity, the hepatic LDL <br />receptor activity was rather increased in animals fed cholesterol with linoleic acid in comparison with control animals (Tables 4 and 5, Fig. 1). This result suggests that <br />fatty acids, especially linoleic acid, independently influence the regulatory pathway of LDL receptors and <br />HMG-CoA reductase activity by cholesterol. <br />http://www.jlr.org/content/31/8/1413.full.pdfPuddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-65673839912282895182013-08-14T14:08:28.106-07:002013-08-14T14:08:28.106-07:00Goji berry is a source of taurine:
http://www.ncbi...Goji berry is a source of taurine:<br />http://www.ncbi.nlm.nih.gov/pubmed/21820420<br /><br />This berry has a hepatoprotective polysacharride effective at normal dietary intakes. Generally I don't believe in superfoods, but Goji seems medicinal for the liver and is used in a modern TCM liver tonic (a mix of goji, and rosa rugosa petal, which contains tellimagrandin 1, an HCV invasion inhibitor).<br />http://www.ncbi.nlm.nih.gov/pubmed/20144544Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-15559314631138515952013-08-09T15:12:09.497-07:002013-08-09T15:12:09.497-07:00From the first link in the post:
hepatic triglycer...From the first link in the post:<br />hepatic triglyceride (Tg) accumulation is not per se toxic, but rather protects the liver by buffering the accumulation of lipotoxic Tg precursors. Consistent with this view, subjects who are able to store excessive fat as neutral cholesterol esters and TG develop steatosis but not NASH and may be considered “good fat storers”, while subjects who are unable to synthesize neutral lipids accumulate toxic lipid species and develop progressive inflammation and fibrosis, leading to NASH. <br /><br />High linoleic acid intakes = poor fat storage. Oleic acid probably promotes healthier hepatic fat storage. Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-77147944106309035202013-08-09T14:52:04.416-07:002013-08-09T14:52:04.416-07:00In the cholesterol accumulation papers, it seems a...In the cholesterol accumulation papers, it seems accumulation promotes oxidation. There is a to-and-fro between oxidation of cholesterol and cardiolipin that affects the mito membrane.<br />And of course the high PUFA levels will make oxidation more likely.<br />And vitamin E has some benefit in NASH, some people responding better than others. http://www.nejm.org/doi/full/10.1056/NEJMoa0907929<br />this was a comparison with the anti-diabetic drug pioglitazone.<br />The soy oil used in the Hashimito experiment was higher in n-6 than I thought: nearly 50pc. So over 20pc energy as n-6.<br />High hepatic cholesterol and NEFAs seems to me like a house of cards, ready for any toxic or immunological trigger to precipitate a less easily reversible pathology.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-45498215479782132452013-08-09T12:14:28.135-07:002013-08-09T12:14:28.135-07:00Wow 2%. That'd be about 10 grams per 2000 kca...Wow 2%. That'd be about 10 grams per 2000 kcal. <br />Probably impossible for a human: 83 eggs = 2000 kcal = 6 grams cholesterol... which leads me to think maybe that "other factor," especially in rodent diets, is oxidized cholesterol. There's probably some naturally occuring non-oxidized cholesterol, but to get 2% would definitely require adding straight cholesterol.Billhttps://www.blogger.com/profile/05022558754270362782noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-12389481634044670532013-08-08T23:48:55.558-07:002013-08-08T23:48:55.558-07:00That's right, it's a set-up for some other...That's right, it's a set-up for some other factor to wander in and take the liver down. Dietary cholesterol maybe, but human intakes don't match the 2% (by weight I presume) that's toxic to these rats.<br />In humans with HCV (which deranges cholesterol homeostasis in its own right), fatty liver is associated with cirrhosis OR 5.0 or thereabouts. And PUFA correlates with steatosis at OR 2.7 or 2.9 if memory serves.<br /><br />The fish oil for NAFLD paper I linked to a while ago looked really encouraging for a review of a supplement intervention. Especially a PUFA supplement in a liver disease.<br /><br />Fish oil TPN I believe is also safer because much less of it is needed. The EFAs are plainly more "essential" than those in soy.<br /><br />I wonder if this omega-6 effect, whatever else it does, promotes diabetes. All those NEFAs, and of course the LA swamping the DHA signal. Maybe the protective role of dairy fat in DM2 is related to what displaces dairy fat in the diet.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-22683322285374500572013-08-08T19:33:09.432-07:002013-08-08T19:33:09.432-07:00Soy alone won’t cause NASH in rodents, especially ...Soy alone won’t cause NASH in rodents, especially in the exceptionally fibrosis-resistant C57’s. They really need methionine and/or choline restriction, which seems to support your point that increased cholesterol synthesis and/or uptake must be accompanied by impaired cholesterol export.<br /><br />Non sequiter: agreed also about the fish oils. Comined with any other insults = detrimental (eg, alcohol); but alone, they are probably beneficial – patients undergoing TPN with Intralipid (soybean oil) are at much greater risk of liver damage than those who are lucky enough to qualify for something like Omegaven which is high in fish oils.<br />Billhttps://www.blogger.com/profile/05022558754270362782noreply@blogger.com