tag:blogger.com,1999:blog-8550919611653842066.post8243640942844891719..comments2023-10-24T19:10:17.771-07:00Comments on The High-fat Hep C Diet: More Cholesterol Madness; Malcolm Kendrick on Viral Hepatitis. Plus, What would Jesus eat?Unknownnoreply@blogger.comBlogger5125tag:blogger.com,1999:blog-8550919611653842066.post-55137279460618202952012-10-02T17:00:14.042-07:002012-10-02T17:00:14.042-07:00A really good read on this subject is "The Qu...A really good read on this subject is "The Queen of Fats" by Susan Allport.<br />It turns out leafy greens are an important source of ALA when the diet contains enough of them (and isn't already full of LA).<br />this may explain the benefits of eating greens... not the fibre, or even the purported antioxidants, but the omegas.<br />The colder the growing conditions the more omega 3. Watercress is probably ideal; seaweeds are even better (some have EPA and DHA as well).Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-42840409144706120802012-09-30T13:06:57.427-07:002012-09-30T13:06:57.427-07:00Arachadonic acid is preserved on VLC in a Volek pa...Arachadonic acid is preserved on VLC in a Volek paper - it is not converted to prostaglandins etc, because of less inflammation/ lower insulin.<br />Robb Wolf has a post on it: http://robbwolf.com/2012/09/06/arachidonic-acid-animal-fats-limit-them/<br /><br />In evolutionary diets we would have been exposed to AA + DHA in good ratios but LA content would have varied seasonally. When eating animals corn-fed year round things might be different.<br /><br />Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-63430379973031093432012-09-30T11:11:29.675-07:002012-09-30T11:11:29.675-07:00That's an interesting study about the downregu...That's an interesting study about the downregulated gluconeogenesis. Nephropal used to write about fish oil increasing adiponectin, which as far as I know is a factor there. Vitamin D is often claimed to do the same, but I remember being unable to find any direct evidence for vitamin D supplementation increasing adiponectin or decreasing gluconeogenesis.<br /><br />When you say that "AA is preserved," do you mean its incorporation into tissue versus its metabolism? I wonder if that itself is something to think about anyway. The AA conversion/synthesis does seem to increase and decrease, at least in rats and mice, which is expected. <br /><br />Linoleic acid is traditionally low, but as you also said on Hyperlipid in response to blogblog, those diets are maybe "new" as well, where there isn't as much reliance on large game and high amounts of fat. I often see the 4%kcal as PUFA mentioned, but that leaves very little room regarding fat sources [if eating high fat]. <br /><br />Johnhttps://www.blogger.com/profile/05161850700121191487noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-39227578889639398942012-09-30T00:58:39.377-07:002012-09-30T00:58:39.377-07:00Of course, if you are eating high fat, you are pro...Of course, if you are eating high fat, you are probably already getting more AA and DHA...<br />It seems to be the case that an extreme of macronutrient intake sometimes alters the fate of the sub-macronutrients (to coin a phrase), the individual fats, sugars and amino acids. For example, the fate of fructose is less problematic, and AA is preserved, when carbs are low.<br />Fats affect blood lipids, but so do carbs; in VLC, does the optimal lipid ratio change to reflect this?<br />For example, very high LDL on a VLC diet (if it means anything, i.e. if it is associated with some other symptom) could obviously be moderated by a higher intake of very long chain fatty acids.<br />And it appears that hepatic gluconeogenesis in mice is decreased by supplying VLCFA; and this is more effective if krill oil rather than fish oil is used.<br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268598/<br />This effect could be useful in some VLC scenarios.<br />Also, in terms of Hep C, adding DHA, AA, and EPA (in order of efficacy) to infected hepatocytes can produce substantial drops in viral replication (I presume that linoleic and maybe linolenic were already supplied in baseline culture medium, being "essential" nutrients)<br />The foods you mention are low in iron, which may justify including them as alternate protein sources.<br />A good omega 6:3 ratio seems to be able to compensate for some effects of higher PUFA intake. So add fish to the list. I cook bacon in dripping, fish with coconut, eggs in butter, use dripping in chicken stuffing, etc, so that VLCFA are preserved in an SFA/MUFA matrix.<br /><br />Before the advent of seed oils, linoleic acid was about 1% of energy, now it is closer to 8%.<br />Is arachadonic acid from diet different, physiologically, from AA formed from excess linoleate? Like cholesterol, does it depress its own rate of synthesis? More questions than answers. <br />Maybe, like a reverse vegetarian with a wartime ration book, the high-O6 white meats can be substituted for nuts and seeds and olive oil.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-82185509365532341192012-09-28T02:03:47.483-07:002012-09-28T02:03:47.483-07:00Hi George,
You made a comment on Hyperlipid about...Hi George,<br /><br />You made a comment on Hyperlipid about a possible increased need for AA and DHA when eating high fat. What is your argument for this?<br /><br />I go back and forth, of course hoping to conclude that your suggestion is correct, as it would be nice to the worry about eggs, duck, goose, pork, etc.Johnhttps://www.blogger.com/profile/05161850700121191487noreply@blogger.com