tag:blogger.com,1999:blog-8550919611653842066.post1041470644620671390..comments2023-10-24T19:10:17.771-07:00Comments on The High-fat Hep C Diet: "The Truth was Still Putting on its Shoes", my first article to be published IRLUnknownnoreply@blogger.comBlogger9125tag:blogger.com,1999:blog-8550919611653842066.post-87272612617847583322013-05-07T14:41:05.724-07:002013-05-07T14:41:05.724-07:00Bill, I think DNL fats are ligands for PPAR-alpha,...Bill, I think DNL fats are ligands for PPAR-alpha, which is the fasting-state "fat burning" transcription factor. This seems paradoxical, but it might well be how coconut oil works.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-67436310384640425332013-05-07T14:37:47.114-07:002013-05-07T14:37:47.114-07:00Does anyone think it's relevant that coconut i...Does anyone think it's relevant that coconut is only a staple food in hot places? I wonder if there is a pattern towards eating more thermogenic foods around nightfall in those places? In fact, is this the original evolutionary reason for the big evening meal in general?Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-71201653210362220582013-05-07T01:23:06.599-07:002013-05-07T01:23:06.599-07:00What does it mean that the coconut rats had to eat...What does it mean that the coconut rats had to eat more of EVERYTHING, not just fat, to keep the same shape as the butter rats?Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-9060404623284087682013-05-06T07:46:23.512-07:002013-05-06T07:46:23.512-07:00Interesting interesting. I tend to think some exo...Interesting interesting. I tend to think some exogenous fats, like George mentioned linoleate also play an important/"causative" role in liver dysfunction. <br /><br />I wouldn't expect MCTs to deteriorate mitochondrial function at any ambient temperature, but even more so in the cold when BAT is already activated. Is this where you guys were going: MCT-induced BAT activity drives DNL to fuel thermogenesis (as opposed to MCTs themselves being burned)?Billhttps://www.blogger.com/profile/05022558754270362782noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-29736559138888083362013-05-05T15:22:32.571-07:002013-05-05T15:22:32.571-07:00The idea that alcohol is not required or sufficien...The idea that alcohol is not required or sufficient in itself to produce AFL is covered very ably in these two papers:<br />fats and AFL: http://download.journals.elsevierhealth.com/pdfs/journals/0016-5085/PII0016508595903542.pdf<br />microbiota and AFL:<br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379693/Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-19650857029895745662013-05-05T15:11:41.080-07:002013-05-05T15:11:41.080-07:00Thanks Ilya. I consider increased ambient heat in ...Thanks Ilya. I consider increased ambient heat in dwellings, workplace, hospitals, cars etc a cause of modern morbidity. I believe that Colorado has the lowest obesity rate in the USA. Mitochondrial dysfunction especially at ETC Complex 1 is common to a wide range of disorders.<br />You can cause steatosis in humans with excess linoleic acid, probably easier if fructose is also included. Human cases of NASH will have extremely high n-6/n-3 ratios; up to 144:1.<br />http://www.kenes.com/easl2010/posters/Abstract221.htmPuddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-17913192918034922912013-05-05T12:33:44.144-07:002013-05-05T12:33:44.144-07:00In view of recent studies housing temp is importan...In view of recent studies housing temp is important with rodents. When kept under 30C rodents are cold-acclimated and display an evolutionary established preference for lipolysis (Walsberg et al.) and respectively active BAT. Energy expenditure obviously was not matched with nutritional intake so in this case BAT of HF fed rats was compensating for both-cold acclimation and excess food intake thru increased thermogenesis hence increased UCP-1 in HD rats. The rest was stored as WAT. Now about the main point of the study, the idea that dietary fats cause NAFL or obesity in humans is long time dead. Cause for NAFL and AFL too is increased hyperglycemia insulin-induced SREBP-1c transcriptional and translational factor in cold acclimated human subjects result of *endogenous* LC acyl-FA, the ones formed from glucose and especially sucrose and fructose via DNL. There is a study from Alcoholic Reports confirming that alcohol is not *necessary* and respectively not a cause for so-called AFL. The reason for increased DNL in humans is the same as in rats, simply the thermoneutrality point is above 33C. Everything below evolutionaty requires lipolysis as predominant metabolic path of Randle cycle. HF LC diets drive DNL to fit that pattern with a detrimental impact on mitochondria causing oxidative stress- from increased NADPH+ ROS (H2O2) and increased NOS (from inhibited AMPK). Final result is mitochondria dysfunction, the one, and founding, cause of modern morbidity.Ilyahttps://www.blogger.com/profile/07710341294288071544noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-21940738324991162312013-05-03T21:25:19.878-07:002013-05-03T21:25:19.878-07:00They were fatter peripherally without changing mas...They were fatter peripherally without changing mass. I am sure there is more to this than muscle wasting, which isn't mentioned in the paper.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-51445895026022109542013-05-03T18:07:56.318-07:002013-05-03T18:07:56.318-07:00It is sort of strange that even the coconut rats w...It is sort of strange that even the coconut rats were fatter, but it does happen sometimes. Their metabolic rate per mass was high though, considering their calorie intake was incredibly high! Johnhttps://www.blogger.com/profile/05161850700121191487noreply@blogger.com