tag:blogger.com,1999:blog-8550919611653842066.post6004977885505122900..comments2023-10-24T19:10:17.771-07:00Comments on The High-fat Hep C Diet: Letters to the EditorUnknownnoreply@blogger.comBlogger15125tag:blogger.com,1999:blog-8550919611653842066.post-2187658067279387122013-05-23T02:52:52.182-07:002013-05-23T02:52:52.182-07:00Good to see you in print, George. Interested in th...Good to see you in print, George. Interested in the link to the Native Diet. What Maori ate in classical times was fascinating. This included quite a variety of fermented food e.g. toroi http://tvnz.co.nz/content/2343025/2527449.xhtml No wonder they had such magnificent physiques in early photos and that's including the old folks! We didn't need to practice genocide, we just gave them the opportunity to adopt our dreadful diet instead.honorahttps://www.blogger.com/profile/01208722334239908985noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-14509196385311991502013-05-18T03:43:10.034-07:002013-05-18T03:43:10.034-07:00That's why I recommend "Right carbs, righ...That's why I recommend "Right carbs, right amounts, right times."<br />For some people, the right amount = 50g/day.<br /><br />I'm still concerned about people who have obviously fat bellies. I don't think that they should go on VLC (~50g/day), due to lack of serum NEFA suppression.<br /><br />LC (~100g/day) is safer for them.Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-89646768755148946492013-05-17T20:23:14.338-07:002013-05-17T20:23:14.338-07:00In my fatty liver post I mention research where vi...In my fatty liver post I mention research where vigorous exercise (only) helps shift liver fat.<br />Vigorous exercise upregulates the same genes as carbohydrate restriction does.<br />i often watch shows like America's Next Top Model where underfeeding is on diplay. I have never thought "that girl needs to move less, a rest would do her good". I wonder if anyone does.<br />There are sometimes good reasons for re-introducing carbs on very low carb diets, but my personal bias is that "re-introduction" is the apposite word. You don't know what you've got till it's gone and everyone should experience a well-fed ketogenic state at least once in their life. I'll go back there if anything is unsatisfactory, like pressing the restart button. Not everyone needs to live there full-time, by any means.<br />Which is why I link to pro-carb sites like Perfect Health Diet and Archevore before others in the sidebar.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-3078242725705758502013-05-17T18:55:31.969-07:002013-05-17T18:55:31.969-07:00George! How could you? ;-) :-D
Liver's don...George! How <b><i>could</i></b> you? ;-) :-D<br /><br />Liver's don't "go to the gym". Stuff goes in & stuff comes out. It's stuff going in faster than stuff coming out chronically, that causes problems.<br /><br />Bill Lagakos tweeted a new study. <a href="http://www.ncbi.nlm.nih.gov/pubmed/23675676" rel="nofollow"><b>http://www.ncbi.nlm.nih.gov/pubmed/23675676</b></a><br /><br />Cliff Notes:- NIDDM: moderate to vigorous physical activity (>15 mins ONCE/wk) = -17% all cause mortality.<br /><br />The Biggest Loser = Massive Facepalm. This doesn't invalidate ELMM. Humans just have a knack for f*cking things up!<br /><br />I am pro low-carb diets for everyone. I am pro very-low-carb diets for slim people only.Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-79521162921437613042013-05-16T20:53:12.781-07:002013-05-16T20:53:12.781-07:00Damn Nigel, I deleted your last comment by acciden...Damn Nigel, I deleted your last comment by accident trying to get to it!<br />This guy (on the right) thinks that the weight-loss industry is harmful to people.<br />http://www.youtube.com/watch?v=-5d-fw5isio&list=UUDo4HyAsT28SL9elBxtRyYQ&index=6&feature=plcp<br />A case in point might be Ajay Rochester, the Australian host of The Biggest Loser, who has gained 48Kg and reportedly fears "eating herself to death". <br />http://www.dailymail.co.uk/tvshowbiz/article-2311201/Ajay-Rochester-gains-48kgs-Im-eating-death.html<br />Clearly her eat-less-move-more efforts and all the expert nutritionists she had contact with on the show have not helped her, and there are good physiological reasons why they may have harmed her.<br />I don't think you and I disagree at base Nigel - eat less crap and move more outdoors. Probably we disagree about carbs a bit. The liver quite clearly gains and loses fat in a very simple Taubesian way, with an extra role for PUFA and fructose, and there <i>is</i> a metabolic advantage (but why does it produce less fatigue or rebound hunger than other energy deficits, is the most interesting question), so I tend to trust such low-carb articles of faith despite the currently incomplete explanations.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-57061391134052889212013-05-16T00:40:53.603-07:002013-05-16T00:40:53.603-07:00Nice letter, George.
Teh Sid.Nice letter, George.<br /><br />Teh Sid.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-20791193719189997992013-05-15T02:49:44.804-07:002013-05-15T02:49:44.804-07:00I think one can use addiction as an analogy. Note:...I think one can use addiction as an analogy. Note: analogy; I do not think that obesity = food addiction is a useful idea overall.<br />Addiction is drug dependence with features of neurological, immunological and metabolic disease.<br />It is caused by exposure to the substance, and the obvious thought is that removing the substance will therefore cure it.<br />Junkies go to detox or prison and completely rid themselves of the drug, yet the disease persists and the rate of relapse is very high. Abstinence introduces new dangers and deaths often occur with re-exposure. <br />But if the underlying disease can be successfully treated, recovery through abstinence may be more or less spontaneous. Age alone is often a curative factor if the addict survives. Ibogaine seems to be able to address the underlying disease, and supplements such as acetyl-n-cysteine, probiotics, and NAC can alter the immunological and metabolic aspects of the condition enough to ease recovery.<br />Understanding and treating the underlying disease before trying to force a change in the symptom (i.e. drug use and drug seeking-behaviour in the case of addiction, or energy intake in excess of output in the case of obesity) is likely to be the most effective and least harmful strategy in all but the most short-term and superficial cases.<br /><br /><br />Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-36091791675353739232013-05-14T20:15:28.032-07:002013-05-14T20:15:28.032-07:00To move more when you're starving may not be t...To move more when you're starving may not be the best idea, you should probably fix those deficiencies, then hopefully you'll want to move more. Also, most mitochondrial diseases seem to involve defects at complex 1 and this part of the ETC is leaned on most heavily when glucose is used to generate ATP. We can basically rest this part of dysfunctional mitochondria, giving them more teeth to generate ATP, with a higher fat diet. (This I got from trying to understand Hyperlipid's series on the FADH2/NADH ratio).<br />If you have a disease that makes you gain weight much too easily, to store energy as it were, the disease needs to be treated. Altering the numbers of the energy inputs and outputs isn't dealing with the disease and may just make it worse. Improving the quality of the inputs, fine-tuning the macronutrients for their metabolic and (if you must) endocrine effects, and fine-tuning outputs (exercise) to those that are specifically likely to be therapeutic, not so much because they expend energy, but because they reinforce the physiological benefits of the other changes; this makes more sense to me as a first step because it is trying to treat the disease, which would, untreated, remain a disease regardless of the current weight as long as one was starving.<br />Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-67603594225972865452013-05-14T19:22:10.643-07:002013-05-14T19:22:10.643-07:00To use your analogy:- To fix the problem, get some...To use your analogy:- To fix the problem, get some dentures for the toothless starving animal.<br /><br />Now, how to fix the problem IRL? How about...<br /><br />Right carbs, right amounts, right times = no hyperinsulinaemic "comas". People start to "Eat less & Move more" spontaneously. Moving more = dentures for toothless mitochondria.Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-48016799719107475952013-05-14T17:41:38.903-07:002013-05-14T17:41:38.903-07:00Yes, that's about right. If what you're ea...Yes, that's about right. If what you're eating crashes your thyroid (not enough retinol, selenium, iodine, protein, calories, or too much gliadin in the wrong immune system) your EE might well nosedive (just for instance, not saying it's all about the thyroid at all). And if you eat more to get it up again, but don't fix the underlying deficiencies, it may be easier for adipocytes to store the extra than it is for mitochondria to burn it.<br /><br />Imagine you are putting food in front of a pleading, starving animal in a cage, but that animal has no teeth and as soon as your back is turned a fatter animal wallows out of the shadows and gobbles up the food. The skinny animal is the mitochondria (perhaps especially the hepatic mitochondria), the fat one is the adipocytes. Well that's one hypothesis: http://www.sciencedirect.com/science/article/pii/0361923085900115Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-65071175817244884492013-05-14T11:39:04.223-07:002013-05-14T11:39:04.223-07:00I believe that the Energy Balance equation always ...I believe that the Energy Balance equation always applies. Unfortunately EE is almost impossible to measure accurately in free-living people (there is doubly-labelled water, but it's horrendously expensive).<br /><br />Some (usually young) people's EEs shoot up when they over-eat, so their weight doesn't change.<br /><br />Other (usually older and going into regular hyperinsulinaemic "comas") people's EEs drop like a stone when they over-eat so their weight (and bodyfat) shoots up.Nigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-29763830231984677952013-05-13T21:25:45.052-07:002013-05-13T21:25:45.052-07:00Indeed, or at least not affected in the direction ...Indeed, or at least not affected in the direction of obesity.<br />I don't dispute the importance of energy, but I won't stand for it being proffered as an explanation for anything. Not least because interventions based on CICO alone don't seem to be very healthy.<br />The poorest people are the most prone to obesity, yet they have the least money to spend on food and comfort, and are the most likely to be malnourished and suffer degenerative illnesses compounded by past overwork.<br />A less nourishing diet combined with more exertion can't be the answer.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-89360231008005092562013-05-13T19:51:08.567-07:002013-05-13T19:51:08.567-07:00There are a lot of people who seems to be not affe...There are a lot of people who seems to be not affected much by our obesogenic environment. <br />Galina L.https://www.blogger.com/profile/09156132815504279615noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-24655150815215443502013-05-13T13:08:50.657-07:002013-05-13T13:08:50.657-07:00Thanks Nigel,
I thought of another way to put that...Thanks Nigel,<br />I thought of another way to put that; everyone who is prone to weight gain knows that they have to watch what they eat, and everyone who isn't, doesn't. If CICO played out as a scientific constant, we would have a level playing field where everyone would be equally prone to weight gain and weight loss. Ergo there are primary factors being overlooked when the secondary one of "ate more, moved less" is put before the horse.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-69630226725409157162013-05-13T08:47:19.003-07:002013-05-13T08:47:19.003-07:00Hi George,
It's a good letter - concise and t...Hi George,<br /><br />It's a good letter - concise and to the point. The only problem that I can see with it is the bit with the Taubsian dig at CICO.<br /><br />Cheers, NigeNigel Kinbrumhttps://www.blogger.com/profile/03368973941328529619noreply@blogger.com