tag:blogger.com,1999:blog-8550919611653842066.post7110367871572094480..comments2023-10-24T19:10:17.771-07:00Comments on The High-fat Hep C Diet: More lessons from Naltrexone and TLR4; AstragalusUnknownnoreply@blogger.comBlogger18125tag:blogger.com,1999:blog-8550919611653842066.post-89334199855993838012013-06-27T15:50:38.970-07:002013-06-27T15:50:38.970-07:00Wow - what a shame I ate so much margarine as a ch...Wow - what a shame I ate so much margarine as a child! Pity that not having eaten it for the past 20 years hasn't fixed the damage done :(karismachttps://www.blogger.com/profile/02514710312063410604noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-66643457729891161432013-06-27T03:48:59.917-07:002013-06-27T03:48:59.917-07:00Have a look at this.
it would be much better with ...Have a look at this.<br />it would be much better with butter and marge consumption split into quintiles or other groupings, the method they use doesn't tell us much.<br />But still.<br />http://onlinelibrary.wiley.com/doi/10.1034/j.1398-9995.2001.056005425.x/full Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-19733046572944716392013-06-24T03:26:21.535-07:002013-06-24T03:26:21.535-07:00Cool I will have a look at the link.
Your hypoth...Cool I will have a look at the link. <br /><br />Your hypothesis about possible increase in allergens in my diet is sound - but I don't think it is the problem. It may be that the last batch of Natto I made has gone a bit mouldy (I am throwing it out and starting over tomorrow) but my main allergy is dust mites which often play up when getting blankets and jumpers out of storage. Still I think the C02 factor could be a part of it. The Exercises they teach on normalbreathing.com are pretty amazing so I will go back to doing them religiously and let you know what happens. I went from someone whose loud breathing used to draw a lot of embarrassing comments and who was bed ridden a lot of the time with allergies and flu symptoms to being very active all day and my breathing being nearly invisible (and hardly ever using my puffer). I am sure I can get back there - I just needed that key bit of info (about the C02) you gave me to get me doing the exercises properly again. It is a PITA to do every day but well worth the benefits! <br /><br />I stopped smoking anything last time I had pneumonia from smoking only one joint after nearly two years off it! I know people say smoking pot helps but they must not have the same kind of lung disease I do!karismachttps://www.blogger.com/profile/02514710312063410604noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-29403563182573653762013-06-24T02:39:49.876-07:002013-06-24T02:39:49.876-07:00Sorry I meant "egg white", a common alle...Sorry I meant "egg white", a common allergen (unfortunately).Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-70929033086289760842013-06-24T02:39:02.078-07:002013-06-24T02:39:02.078-07:00That's very interesting. Asthma may be worse b...That's very interesting. Asthma may be worse because you are introducing more of some allergen (dairy protein, milk white, beef) you avoided before. Or because there are cells dependent on glucose and carbs are too low to feed these (if you are very low-carb it might take time to adjust, it's often not easy nor necessary to go very low).<br />LDN I can't find much data on LDN and asthma. In theory it could help, and it's not very toxic even at normal high doses. Some good data here:<br />http://www.doctordeluca.com/Library/References/Nal_Hepatic_Tox.htm<br /><br /><br />Orthomolecular treatment of asthma uses high-dose vitamin C: 1,000mg per hour until "bowel tolerance". I don't know anyone who's tried this. Most of my friends smoked pot for it.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-53786636369847220492013-06-23T20:39:39.677-07:002013-06-23T20:39:39.677-07:00Okay what you say about the C02 explains something...Okay what you say about the C02 explains something weird I had noticed since going on the high fat low carb diet. <br /><br />The best help I have had with breathing is a site you might like www.normalbreathing.com <br /><br />The Russian doctor whose site that is teaches that C02 actually heals our lungs and allows our blood to carry more oxygen. So doing his exercises I had already slowed down my breathing by raising my bodies natural trigger level to C02. I guess a way to describe it would be that I have trained myself to be tolerant to higher levels of C02, which has helped my lungs and slowed down my breathing. <br /><br />So when I started this diet a few weeks ago I noticed right away that to get the same breath holding time each day only took me about 5 minutes instead of 12. <br /><br />I don't really enjoy the exercise so I thought oh great I am done now and I have just been stopping when my breath holding time gets to the same duration that it used to after 12 minutes. <br /><br />But even though my breath holding time (or it is also called your control pause -- meaning how long a time you can pause with your lungs empty between breaths) is higher than ever my lung inflammation (asthma) has been worse than it has been in a long time. <br /><br />So what you say explains all of that. Since you say my respiration is producing less C02 I will still need to do the exercises for the full 12 minutes and expect my breath holding time to be much higher than before to get the same positive results for my lung inflammation. <br /><br />I am getting up to about 50 seconds right now - so I will see how high my BHT gets when I start doing the full exercise again. I have never been over a minute so this will be interesting. <br /><br />BTW - This is not the amount of time you can hold your breath once - but repeatedly with controlled breathing. When I started the exercises a year ago my BHT was only about 9 seconds! <br /><br />Anyway I thought I would share this in case anyone with asthma on this diet finds it useful. <br /><br />Hey but George you haven't mentioned LDN and if you think it is worth trying for my asthma? I have a friendly doctor now but I would still have to give her some research etc. as to why I want to try it. <br /><br />Normally I avoid prescription drugs unless they are absolutely necessary but I have heard so much about LDN being a wonder cure for so many things I can't help but be curious? <br /><br /> <br /><br />karismachttps://www.blogger.com/profile/02514710312063410604noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-7483635213546058882013-06-23T13:17:02.096-07:002013-06-23T13:17:02.096-07:00Yes asthma is an auto-immune disease. It is rare i...Yes asthma is an auto-immune disease. It is rare in children raised on farms who are exposed to more microbes, and in people who test positive for hepatitis A. A dirtier lifestyle might protect against it.<br />TLR2 and TLR4 are involved which are targets of spirulina (TLR2) and probiotics (TLR2 and TLR4), but experiments with probiotics don't produce much result except in newborns. Hopefully shifting to a lower-carb, more saturated fat diet will help, as breathing is one of the areas that benefits. On a high-fat diet cellular respiration produces less CO2 (per calorie) so the impulse to exhale is lessened and breathing can be slower and steadier.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-52986578418810787382013-06-23T03:14:22.003-07:002013-06-23T03:14:22.003-07:00Thanks George, Yes probiotics are great and I foun...Thanks George, Yes probiotics are great and I found the strain you recommend in Vaalia yoghurt and am culturing it myself with raw milk. That and the Spirulina are so potent - who needs drugs when you can feel like superman everyday :) <br /><br />I wonder is asthma an auto immune disease? Do you think low dose Naltrexone would help with that?<br /><br />Anyway thanks again for all your amazing research and I like the music too :) I used to sing in a post punk band back in the day - good to see that some folk are still at it!karismachttps://www.blogger.com/profile/02514710312063410604noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-77182271621441999262013-06-23T00:44:02.288-07:002013-06-23T00:44:02.288-07:00My own experience has been that niacin or niacinam...My own experience has been that niacin or niacinamide are fine to take. Just stay away from high-dose time-release niacin. Niacinamide has an antifibrotic profile, the way niacin works is more obscure but it can definitely help at lower doses (such as 250mg a day). The no-flush niacin is good too. It's not essential but OK if it works for you, especially around moods, comfort, and (niacinamide) sleep.<br /><br />The article is technical background stuff and relates more to good probiotics, some herbs like astragalus/cordyceps, and getting the right fibre (and amount thereof) for your needs.<br />Naltrexone is especially valuable when HCV causes autoimmune problems, mood problems, low immunity.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-74422967625157736012013-06-22T02:58:05.468-07:002013-06-22T02:58:05.468-07:00Oh and I am taking Selinium, ALA, Milk thistle, Ca...Oh and I am taking Selinium, ALA, Milk thistle, Calcium magnesium vitamin D and C. I will also start taking E again soon when I find a good mixed tocoferols one. <br />I don't know what my viral load is yet but am asking the doctor on Monday. karismachttps://www.blogger.com/profile/02514710312063410604noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-11664692051330117292013-06-22T02:09:02.901-07:002013-06-22T02:09:02.901-07:00Hi George,
Thank you so much for all of your rec...Hi George, <br /><br />Thank you so much for all of your recommendations on this blog. You have really done your research. <br /><br />I have commenced a high fat very low carb diet, am taking spirulina every day and have thrown out the brahmi supplements I was taking that had Ginko and B6 (pyridoxin) in them along with eating breakfast. I am eating a lot of lamb, pate, avocados, eggs, mackerel and other great food. (I cheat and have a carb meal once a week)<br /><br />I feel great and have a very good feeling about this regime but as I cannot understand any of this article above I wonder if you can tell me - should I be asking my doctor if she will put me on lose dose Naltrexon? I also wonder if I should be taking Niacin? <br /><br />I used to take about 250 mg a day but I have run out and don't know what you think about Niacin and the dosage? <br /><br />I also have asthma but can't bring myself to consider eating shit!!!! I wish I had a well :-) <br /><br />Anyway thanks again- you are a real life saver. karismachttps://www.blogger.com/profile/02514710312063410604noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-75521575702994150842013-04-09T21:08:42.303-07:002013-04-09T21:08:42.303-07:00Most of the benefit of the red meat is probably du...Most of the benefit of the red meat is probably due to its fat, but it is also a source of zinc and selenium, carnitine and carnosine, and omega 3s. <br />Iron is just one factor, and though I like to see it low, I don't want to give it too much importance if everything else is going fine.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-13153554967726981772013-04-09T20:38:10.920-07:002013-04-09T20:38:10.920-07:00This is a good point Un Kim.
I recommend consumpti...This is a good point Un Kim.<br />I recommend consumption of beef and lamb fat (dripping) or dairy fat(I see them as interchangable, fat is better than butter for some types of cooking). As for meat, I tend to follow the Perfect Health Diet protein recommendations these days. So I might have 2 bacon rashers with breakfast and one large chop at dinner; most calories would come from fats including cream and butter used to cream puree and sautee vegetables. I choose fattier meats like lamb. I would have red meats for dinner perhaps 4 nights a week.<br />I did eat much more meat at one time, but my ferritin rose above 200, it is decreasing now. Like you I find dairy fats a great source of energy, and limit meat to my protein needs. I also eat fish, pork, eggs, chicken, tahini, cheese, offal, and occasionally well-cooked dahl as protein foods.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-81029672948990632172013-04-09T02:53:20.663-07:002013-04-09T02:53:20.663-07:00Hi George, you suggest that red meats are protecti...Hi George, you suggest that red meats are protective of liver disease. However, red meats are rich in iron, which we all know promote the progression of chronic hepatitis (apparently, the hepatitic viruses will try to raise your iron stores). Can you explain why you recommend consumption of red meats (i.e beef)?<br /><br />This is not an attack, but just my expression of concerns. I am recenlty limiting my consumption of red meat, and try to get saturated fat from dairy sources. Un Kimhttps://www.blogger.com/profile/04902256264534702798noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-78241765769540500482013-04-03T01:21:36.999-07:002013-04-03T01:21:36.999-07:00LPS is implicated in elevated ferritin:
Cytokines...LPS is implicated in elevated ferritin:<br /><br />Cytokines also regulated ferritin postranscriptionally. In the Hep G 2 hepatic cell line, induction of ferritin synthesis was observed with a number of cytokines: IL-Iβ, IL-6, TNF-α [2324].<br /><br />Secretion of ferritin is stimulated by cytokines. In primary cultured human hepatocytes, IL-1α and IL-6 induced a transient secretion of ferritin at 24 hr followed by a decline to baseline, whereas TNF treatment result in a sustained increase in ferritin secretion, reaching a level 10 times that found in untreated cells. Cytokines play a pivotal role in the cellular response to infection and ferritin plays a prominent role in the cytokine response. Lipopolysaccharide (LPs), a component of the outer membrane of gram-negative bacteria, elicits a variety of reactions that involve ferritin LPS administered endotracheally to rats induced ferrritin protein expression.<br /><br />http://archive.ispub.com/journal/the-internet-journal-of-laboratory-medicine/volume-3-number-2/ferritin-a-multidimensional-bio-marker.html<br /><br />Insulin also promotes ferritin expression.Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-13405279977911650622013-03-27T12:14:17.321-07:002013-03-27T12:14:17.321-07:00Indeed I do.
Both PUFA and carbohydrate seem to be...Indeed I do.<br />Both PUFA and carbohydrate seem to be drivers for these processes.<br />FFAs are TLR4 ligands hence DM2 is an added risk factor.<br />NF-kappa beta downstream from TLR4is driven by mito ROS...Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-65764318509676119812013-03-26T23:37:17.959-07:002013-03-26T23:37:17.959-07:00Excellent George. I keep being driven to the impor...Excellent George. I keep being driven to the importance of fibroblasts in cancer nourishment and PUFA in the same, especially in the liver. This is all way above the level of physiology I've been picking at for the last few months but you can see how they might fit together...<br /><br />PeterPeterhttps://www.blogger.com/profile/14527788116058656094noreply@blogger.comtag:blogger.com,1999:blog-8550919611653842066.post-27997959907365874512013-03-25T02:35:50.645-07:002013-03-25T02:35:50.645-07:00Hepatology. 2013 Jan 8. doi: 10.1002/hep.26234. [E...Hepatology. 2013 Jan 8. doi: 10.1002/hep.26234. [Epub ahead of print]<br /><br />TLR4 activity protects against hepatocellular tumorigenesis and progression via regulating the expression of DNA repair protein Ku70(1).<br /><br /><br />Hepatocellular carcinoma (HCC) is a devastating consequence of chronic inflammatory liver diseases. We recently find that inhibition of TLR4 promotes tumor metastases. We aimed to investigate whether TLR4 activity contributes to HCC initiation and progression in mice. A mouse model of diethylnitrosamine (DEN)-induced HCC was generated with wild type and TLR4 mutant mice and the development and progression of HCC and senescent responses were assessed by morphologic, immunological and biochemical criteria. We found that genetic or pharmacologic blocking of TLR4 increased susceptibility to DEN-induced HCC carcinogenesis and progression, which was indicated by the increases in tumor nodules, tumor volume and animal death. The enhanced HCC associated with a broad-spectrum reduction of immune response to DEN liver injury as indicated by decreases in the liver-infiltrating F4/80+ macrophages, the ASK1/p38 MAPK/NF-κB and IRF3 signaling activities, and the expression of inflammatory cytokines. Suppressed immune networks resulted in a halt of cellular senescence induction in TLR4 mutant liver tissue, which promoted proliferation and suppressed programmed cell death. Moreover, TLR4 mutation resulted in a suppressed capacity of DNA repair due to a decrease in TLR4-mediated expression of DNA repair proteins Ku70/80 in liver tissue and cells. Isotopic expression of Ku70 in TLR4 mutant mouse restored senescence and interrupted the positive feedback loop of DNA damage and oxidative stress, which reversed TLR4 mutation-deteriorated HCC carcinogenesis and progression. <br />CONCLUSIONS: TLR4 plays an integrated defense role against HCC carcinogenesis by enhancing the expression and function of DNA repair protein Ku70. Our studies provide novel insights into understanding of TLR4 activity in the regulation of HCC tumorigenesis which may be useful for the prevention of HCC development. (HEPATOLOGY 2013.).<br />Puddleghttps://www.blogger.com/profile/00953398103675945541noreply@blogger.com