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Sunday, 15 May 2022

Vegetarianism - a warning from history Pt 2 - Shelly's vegetarian experiments.

Vegan diets and the risk of deficiency diseases – the story of Shelly

One of the earliest objective accounts of the effects of a vegetarian diet in English is Thomas Love Peacock’s observations of his friend, the poet Percy Bysshe Shelly. I think these are interesting because Shelly’s ordeal is very similar to what enthusiastic young people subject themselves to today, and because Peacock’s dry humour can speak for the rest of us.
Quotes are from Thomas Love Peacock’s Memoir of Percy Bysshe Shelly.

Shelly had come under the influence of JF Newton, author of The Return to Nature, or A Defense of the Vegetable Regimen.

Peacock wrote of Newton “He was an estimable man and an agreeable companion, and he was not the less amusing that he was the absolute impersonation of a single theory, or rather of two single theories rolled into one. He held that all diseases and all aberrations, moral and physical, had their origin in the use of animal food and of fermented and spirituous liquors; that the universal adoption of a diet of roots, fruits, and distilled water, would restore the golden age of universal health, purity, and peace ; that this most ancient and sublime morality was mystically inculcated in the most ancient Zodiac, which was that of Dendera…”[I will spare you Peacock’s lengthy exposition of this astrological system]

“At Bracknell, Shelley was surrounded by a numerous society, all in a great measure of his own opinions in relation to religion and politics, and the larger portion of them in relation to vegetable diet”
Shelley had published the treatise, A Vindication of Natural Diet, in 1813.
But Peacock was skeptical of Shelly’s claims to superior health;

His vegetable diet entered for something into his restlessness. When he was fixed in a place he adhered to this diet consistently and conscientiously, but it certainly did not agree with him; it made him weak and nervous, and exaggerated the sensitiveness of his imagination. Then arose those thick - coming fancies which almost invariably preceded his change of place. While he was living from inn to inn he was obliged to live, as he said, ' on what he could get '; that is to say, like other people.  When he got well under this process he gave all the credit to locomotion, and held himself to have thus benefited, not in consequence of his change of regimen, but in spite of it. Once, when I was living in the country, I received a note from him wishing me to call on him in London. I did so, and found him ill in bed. He said, ' You are looking well. I suppose you go on in your old way, living on animal food and fermented liquor ?' I answered in the affirmative. ' And here,' he said, ' you see a vegetable feeder overcome by disease.' I said, ' Perhaps the diet is the cause.' This he would by no means allow ; but it was not long before he was again posting through some yet unvisited wilds, and recovering his health as usual, by living ' on what he could get '.

In Edinburgh he became acquainted with a young Brazilian named Baptista, who had gone there to study medicine by his father's desire, and not from any vocation to the science, which he cordially abominated, as being all hypothesis, without the fraction of a basis of certainty to rest on. They corresponded after Shelley left Edinburgh, and subsequently renewed their intimacy in London. He was a frank, warm-hearted, very gentlemanly young man. He was a great enthusiast, and sympathized earnestly in all Shelley's views, even to the adoption of vegetable diet. He made some progress in a translation of Queen Mab into Portuguese. He showed me a sonnet, which he intended to prefix to his translation. It began — Sublime Shelley, cantor di verdade !
and ended — Surja Queen Mab a restaurar o mundo.
I have forgotten the intermediate lines. But he died early, of a disease of the lungs. The climate did not suit him, and he exposed himself to it incautiously.

On our way up, at Oxford, he [Shelly] was so much out of order that he feared being obliged to return. He had been living chiefly on tea and bread and butter, drinking occasionally a sort of spurious lemonade, made of some powder in a box, which, as he was reading at the time the Tale of a Tub, he called the powder of pimperlimpimp. He consulted a doctor, who may have done him some good, but it was not apparent. I told him, If he would allow me to prescribe for him, I would set him to rights." He asked, ‘What would be your prescription ? ' I said, ' Three mutton chops, well peppered/ He said, ' Do you really think so? ' I said, ' I am sure of it." He took the prescription; the success was obvious and immediate. He lived in my way for the rest of our expedition, rowed vigorously, was cheerful, merry, overflowing with animal spirits, and had certainly one week of thorough enjoyment of life.

(There is a confirmation of Peacock’s statement above in a letter Shelly wrote to Hogg in September, 1815, 'on my return from a water excursion on the Thames,' in which Shelley remarks that 'the exercise and dissipation of mind attached to such an expedition have produced so favourable an effect on my health, that my habitual dejection and irritability have almost deserted me.’)

At the time of publishing A Vindication of Natural Diet, Shelly was subject to bizarre hallucinations and phobias, an example of which is given below by Peacock

About the end of 1813, Shelley was troubled by one of his most extraordinary delusions. He fancied that a fat old woman who sat opposite to him in a mail coach was afflicted with elephantiasis, that the disease was infectious and incurable, and that he had caught it from her. He was continually on the watch for its symptoms ; his legs were to swell to the size of an elephant's, and his skin was to be crumpled over like goose-skin. He would draw the skin of his own hands, arms, and neck very tight, and if he discovered any deviation from smoothness, he would seize the person next to him, and endeavour by a corresponding pressure to see if any corresponding deviation existed. He often startled young ladies in an evening party by this singular process, which was as instantaneous as a flash of lightning. His friends took various methods of dispelling the delusion. I quoted to him the words of Lucretius : —

Est elephas morbus, qui propter flumina Nili Gignitur Aegypto in media, neque praelerea usquam. *

He said these verses were the greatest comfort he had. When he found that, as the days rolled on, his legs retained their proportion, and his skin its smoothness, the delusion died away.

* the gist of this quote seems to be that elephantiasis is only generated from the waters of the Nile.

Monday, 21 March 2022

Is Acetaminophen (Paracetamol) use making the Covid-19 pandemic worse?

I've written in an earlier post about what's wrong with recommending paracetamol to people with Covid. There are no RCTs to show it's safe, and there are undisputed findings from toxicology and Covid-10 pathology which, taken together, suggest a potential for danger,[1]

Paracetamol overdoses used to kill around 200 people a year in New Zealand according to data which was regularly published in the 1970's and 1980's. Today the policy is to censor any information related to suicide. Does this work? On the one hand copy-cat effects are easy to confirm in real life, on the other hand the problem seems to have gotten worse overall under this "hear no evil" policy.
At any rate, deaths due to paracetamol fell sharply when Parvolex (NAC) was introduced as an antidote (which happened much later than it should have, and today the standard treatment seems to be reduced glutathione.[2]
Paracetamol (acetaminophen) metabolises to a free radical, which peroxidises lipids within the liver, causing liver failure. Glutathione, a reduced antioxidant peptide renewed by selenium enzymes, is the primary defense against lipid peroxidation. Lipid peroxidation is how SARS-CoV-2 destroys the lungs. The toxic metabolite is formed by CYP450 E21 enzyme degradation. In animal models, a diet high in polyunsaturated fat (the most peroxidizable fatty acids) and low in protein (the source of glutathione) accelerates liver damage caused by paracetamol toxicity - diets high in saturated fats and protein are protective.[3]

It's been suggested, based on a rational understanding of processes which as I've said are nowhere being disputed, that paracetamol, by increasing glutathione consumption, will have adverse effects on the people most vulnerable to Covid.[1]

To be honest I thought these effects were likely to be swallowed up in the noise of covid interactions, and appear as quite small risks in epidemiology until things were better understood.
I was wrong.[4]

METHODS: We conducted a retrospective analysis of patients admitted at Washington Hospital Center between February 2020 and- June 2020. Patients older than 18 years of age, diagnosed with COVID-19 were included in the study. Those who were directly admitted to the ICU were excluded. Acetaminophen exposure was calculated using a formula for average adjusted daily acetaminophen: total acetaminophen divided by number of day’s medication was administered. Groups were stratified to non-exposed and exposed. Within the exposed groups, we further divided them into moderate (100-1000 mg/day) or high exposure(>1000 mg/day). Comparison between groups for continuous variables was conducted using Kruskal Wallis test. Association between two categorical variables was tested using Fisher's exact test.

RESULTS: The cohort included 524 patients with non-exposed (n=136), moderate exposure (n=256), and high exposure (n=132) categories. Multivariable logistic regression showed that patients who were exposed to acetaminophen had a significantly higher odds of being triaged to a higher level of care [3.01 (CI 1.4-7.07 p <0.007) in moderate exposure group and 3.44 (CI 1.49-8.54 p<0.005) in high exposure groups]. Secondary outcomes included longer length of stay (5 vs 10 days, p < 0.001), higher mortality (5.1% vs 16.5% p = 0.001) and higher risk of requiring the ventilator support (2.9% vs 15.5% p<0.001) in the exposed group.

CONCLUSIONS: Previous studies have demonstrated that up to 85% of patients with COVID-19 develop fever and acetaminophen is commonly used as a treatment. Our study showed that acetaminophen exposure was associated with worse outcomes. Further studies are required to investigate this association, in particular to see if having a greater number of febrile episodes is independently associated with these same outcomes.[4]

Those are huge ORs. It's possible that fever itself, for which the paracetamol is being given, instead predicts the outcome.

In this paper, fever is associated with a 4x higher rate of adverse outcomes.[5]  This is concentrated in the symptomatic febrile cases, of whom only 4.8% received NSAIDs. Of course some studies say paracetamol is not an NSAID, others say it is, so it's possibly not even recorded correctly. However, as stated, this is a low correlation between fever and NSAID use, one which would not strongly support confounding-by-indication if it applied to the first paper..

So we have an unsatisfactory situation - a drug that WAS NEVER TESTED is being widely used by people with COVID-19. It's now associated with them getting worse. This could be due to confounding-by-indication, but no-one knows yet.

It's been three fucking years. I'm trying to follow the science, but it's always nodding off.

This post originally appeared on my Patreon blog. If you want to support my researches for a minimal donation, please become a subscriber.


 Sestili P., Fimognari C. Paracetamol-Induced Glutathione Consumption: Is There a Link With Severe COVID-19 Illness? (2020)  Frontiers in Pharmacology,  11, art. no. 579944  


3] Hwang J. Diets with corn oil and/or low protein increase acute acetaminophen hepatotoxicity compared to diets with beef tallow in a rat model. Nutr Res Pract. 2009;3(2):95-101. doi:10.4162/nrp.2009.3.2.95

4] Manjani L, Desai N, Kohli A, Arya R, Woods C, Desale S. Effects of acetaminophen on outcomes in patients hospitalized with COVID-10. Presented at: CHEST 2021; October 17-20, 2021; Orlando, FL/Virtual. Abstract  A1072.

5] Chew, N W et al. “Fever as a predictor of adverse outcomes in COVID-19.” QJM : monthly journal of the Association of Physicians vol. 114,10 (2021): 706-714. doi:10.1093/qjmed/hcab023 

Wednesday, 2 February 2022

Vegetarianism and the Occult - A Warning from History

This post first appeared early last year as a paywalled post on my Patreon blog. If you want to support my esoteric dietary researches, become a subscriber!

The following is an excerpt from a book by Dion Fortune - Moon Magic, most likely.
Fortune was an influential UK occultist who codified the esoteric practice of her time for the mass public. Although she died, of leukaemia, in 1948 her books later became widely-read at a time of heightened interest due to the counter-culture and modernist disruption of traditional religious and scientific belief systems.
Her observations are drawn from her personal experience of the sector of British society in which vegetarian practice was most common - the lunatic fringe.

       "The question of diet also requires to be considered in this connection. The widespread propaganda of the Theosophical Society has caused vegetarianism to be regarded as a sine qua non of occult training. This, however, is not the case. The Western Esoteric Tradition does not make vegetarianism any part of its  system, but teaches that a man should partake sparingly and temperately of the food of the land in which  he finds himself. Personally I am inclined to think that occultism and vegetarianism are apt to be an injudicious mixture for a European, the result being a hyper-sensitiveness that makes life very difficult in our hard-driving civilisation.

      Vegetarianism has to be thoroughly understood and exceedingly well done if it is to be successful, and even so, there is a goodly proportion of people who are incapable of digesting vegetable proteins, which are not nearly so easily dealt with as animal substances. Nothing but experience and experimentation can show whether a vegetarian diet suits a given person. Indigestion is not the only indication that all is not well. Loss of appetite, loss of energy, loss of weight, or a flabby stoutness are all danger signals which if disregarded will cause chronic ill-health.        Vegetarianism may agree with a person well enough at first, but after a considerable period, possibly years, they may find that they are becoming subject to neuritis, neuralgia, sciatica, or one or another of the nerve pains. This is a sure indication that a vegetarian diet is affording insufficient nourishment, not because it does not contain the necessary food units, but because the digestion is unable to assimilate them and they are passing out of the body unchanged. Wherever there is a history of neuralgic pains complicating a case of psychic disturbance, I should be inclined to suspect chronic malnutrition as the cause of a hypertrophied psychism. In such cases it will probably be found that a gradual return to a nourishing mixed diet will bring about a reduction of the hyper-sensitiveness, the undesirable contacts that have been formed will fade, and the condition return to normal. The change of diet, however, should always be made gradually lest the digestion be upset." 

Thursday, 6 January 2022

Yes, but, what will you do when the Covid comes?

This post was originally published on Patreon. You don't have encourage the speculations of the likes of me, but if you want to try, please subscribe!   Every day on NZ twitter people are debating what they would do were they the Government about vaccine roll-outs, MIQ, lockdowns, DJ's, and any other thing they can think of that they have absolutely no influence over.

Maybe, like me, you're double-chipped, using the app, wearing the mask, and annoying AF. Maybe you're even boostered up the wazoo. Well done. But y'know what? You're probably going to catch covid. Even if you don't, someone you care about is going to, even if you no longer care about the unvaccinated except as targets of your spite.

And yet, what no-one is talking about, or better yet arguing about in order to straighten out, is what they're doing now to reduce their risk of taking up hospital space when that happens, and what they're going to do to make themselves feel better once they get sick.

The good news is that the symptoms of Omicron are basically flu symptoms - scratchy throat, muscle ache, fatigue, night sweats, no loss of smell of taste. These, apart from the cough, were basically the second shot vax effects for many people. And even for those hospitalised, the average stay is 4 days vs 8 days with Delta. But why go to hospital at all if you can help it? Some people - morons, mostly - posit a false dichotomy between government policy and personal responsibility. But in every area, these are on completely different planes and complement each other. You taking responsibility for your health eases the pressure on a government trying to help those unfortunates who can't or won't.

So without further ado, as they say in places where there is an oversupply of further ado, here are the things I do.

Firstly, I exercise regularly and keep the sugar, seed oil, and refined starch real low; another way of saying this is that I eat whole food (of the cheapest sort, e.g. eggs, mince, the fruit and vege in season), play frisbee or swim every day, and walk the dog. I get as much sun as I can handle, and will take vitamin D in winter, or after a while during the prolonged cloudy weather typical of much of NZ.

Secondly, I eat a little sauerkraut or yoghurt with my meals, or take a cheap probiotic.

Thirdly, I take some supplements - Clinicians Selenium drops (Sodium Selenite), around 150 mcgs (three drops) a day, and x4 if I think I'm coming down with an RNA virus. This works out at around $17 a year. The cheapest Zinc tabs from chemist warehouse, one a day, but mostly when exposure is likely.  The cheapest chelated magnesium in the supermarket, 150 mg, most days (but I was taking this already).

If I get sick or obviously exposed, I'll increase the selenium drops to 300mcg 2x daily and take Sanderson's ViraMax, a mixture of elderberry (great, works for flu), echinacea, (great, works for cold), olive leaf extract (olive leaf extract has never worked for me, ever), and andrographis (works very well for all viral respiratory infections, but has a rare side-effect risk of liver damage, probably in people with compromised antioxidant defenses). When I had the RSV last year this combo eliminated symptoms so quickly I wondered if I'd just imagined coughing, sneezing and snotting all over the place on the first day.

Maybe you have different ideas? Please discuss them here or in a public forum.

Wednesday, 1 December 2021

My review of selenium, probiotics and vitamin D for COVID-19, meat for mental health, and LCHF for diabetes reversal in MSM

Greetings readers!

Every so often I am asked to review new or best-selling books related to diet for Newsroom and am encouraged by the Reading Room editor Steve Braunias, a very fine writer indeed, not to hold back.

Here's my "review" of two books on vegetables, which is mostly on the role of selenium, probiotics, and vitamin D in the Covid pandemic, as well as the value of meat in the preservation of mental health, and the promise of LCHF, keto and fasting diets for type 2 diabetes remission.

The more clicks and readers it gets, the more chance I'll have of presenting these types of ideas in mainstream media forums in future.

Monday, 22 November 2021

The Mother of all Conspiracies; Oswald and JFK in the 21st Century.


Imagine a counterfactual America, an alternative history wherein it has always been a well-known and accepted fact that Lee Harvey Oswald, a lone-wolf Marxist, had assassinated the President of the United States for rational Marxist reasons as well as subterranean personal ones. In this America, a school shooting by a paranoid vegan only encourages logical and evidence-based discussion of gun control and mental illness, a terror attack by Islamist hijackers is unanimously attributed to its obvious perpetrators, the Moon is American, and one cannot simply say that one has won an election which one has lost. It is an America in which Dr Fauci can sleep easy, and in which, sometimes, a virus is only a virus.
There were conspiracy theorists before JFK of course, indeed Oswald had tried to kill one of them, General Edwin Walker, the only human target he missed putting one or more bullets into. Yet the creative JFK theories have had a wider appeal across American society than the paranoic blend of European antisemitism and John Birch anti-communism indulged in by Walker and his contemporaries. Robert Kennedy, as Attorney General, tried to have Walker committed after he incited the Mississippi University race riots in 1962, but libertarian psychiatrist Thomas Szasz, opposed to the coercive psychiatry that was, to be fair, something of a public menace at the time, talked him out of it. Most people knew Walker was nuts. But with JFK theory you can stay respectable enough, it’s a hobby that seems to hurt no-one. You can put your own choice of villain in the frame – the CIA, the FBI, the Mafia, LBJ, the military-industrial complex, and of course the Cubans or the KGB, though it’s strange that the Manchurian Candidate option presented in film before the assassination – because it seemed believable at the time – hasn’t survived in the modern myth, which is comprised of scenarios entirely discordant with Oswald’s personal beliefs.

We know what Oswald’s political beliefs were because he wrote them down, and expressed them relatively freely to those around him, and we know how he wanted to express those beliefs because we have a reliable witness to his development as an assassin, Marina Oswald, née Prusakova, whom he married in Minsk during his defection to the USSR. A year after Lee’s death, Marina spent several months with Priscilla MacMillan, author of Khrushchev and the Arts; the Politics of Soviet Culture 1962-1964. (MacMillan, a friend of Kennedy’s, had also interviewed Lee Oswald during his defection to the USSR, at which time he told her “I want to give the people of the United States something to think about” - she was the only person to know both the assassin and his victim). The book that resulted, Marina and Lee, did not appear till 1977.
Marina Prusakova, who was not told her father’s identity but came to assume he had died in a purge, and who was rejected by her mother and step-father, was raised for a time by her devout grandmother in an Old Regime style. She had sensibly decided, from her observations of Soviet life growing up, that politics was a sickness and that anyone interested in politics was sick, but she made a fateful exception for the young American who was interested in her. Marina may not have been “political” but she knew a thing or two, as this statement to a Warren Commission interviewer shows:

I look at America. It’s all wonderful. But you go to the damn grocery store and it’s 200 varieties of cereal and basically it’s only oats, corn – how many things? Just so someone can make an extra million off of that. It’s just so unnecessary. If that’s progress, if that’s abundance, how stupid is it of us to want it? Three hundred bags of poison, maybe only two or three good – that kind of progress…I don’t think we should strive for.

Lee Harvey Oswald’s solitary Marxism was the ideology that allowed an intelligent young man to compensate for the loss of his father and an upbringing by one of history’s more blameable mothers. It provided him with inspiration for grandiose fantasies and daring acts, as well as a feeling of intellectual importance that compensated for learning difficulties, diagnosed posthumously as dyslexia. Oswald had become seriously interested in politics at the age of 15 or 16 after he was handed a leaflet about Julius and Ethel Rosenberg, who had been executed some two years earlier for spying for the Soviet Union, on a street corner in the Bronx (the effect this interaction had on him may have influenced his later decision to hand out Fair Play for Cuba pamphlets in New Orleans; it seems to have also triggered a Walter Mitty fantasy life as an espionage hero which lasted the rest of his life). “I was looking for a key to my environment, and then I discovered socialist literature,” Oswald wrote in his diary. “I had to dig for my books in the back of dusty shelves of libraries,” although according to Priscilla McMillan, he came across more as the naïve angry young man than a perceptive Marxist in their 5-hour Moscow interview despite using “a good deal of Marxist language”. The Oswald that stalks the pages of Marina and Lee is also a familiar character to readers of criminal profiling books, a case-study of the violent malcontent male loner. An American outsider who married a Russian outsider, and who was closer to Russian-speaking outsiders than to anyone else outside his family back in the USA, Lee Oswald read Orwell and Dostoyevsky, listened to Rimsky-Korsakoff, Chaliapin, Rachmaninov, and Tchaikovsky, and in his more constructive activities was inspired by Marxist newspapers The Worker and The Militant. He is holding copies of both these papers in the famous photographs Marina took of him with his guns, one of which, with a Russian inscription on the back – “hunter of fascists – ha ha ha!” in Marina’s hand, signed by Oswald, was given to their friend George De Mohrenschildt, the edgelord of the Dallas Russian émigré scene who parodies an éminence grise role in their story. The Worker was the paper of the U.S. Communist Party, The Militant of the Trotskyist Socialist Workers Party; Oswald corresponded with both journals, in a futile attempt to establish credibility as a leader of the organized left; the March 11 1963 copy of The Militant he is holding contains a letter headed “News and Views from Dallas”, signed LH, which was the high point of his association with organised socialism in America.

Lee Oswald was a person who would lie or withhold the truth whenever possible, so that he moved in a web of misdirection, but also presumably in a state of tension lest his lies (which include a long list of needless lies on official forms) be found out. He starved himself and Marina, as his mother had starved him, and pinched pennies as she had - what conspiracy asset would have been left as bereft of financial support as the Oswalds were at times, or as dependent on the kindness of strangers, who liked Marina but rarely liked ungrateful and ungracious Lee, and sometimes feared him? He was violent and controlling towards Marina, and beat her often, but became less violent at home after his attempted assassination of General Walker altered their relationship; he was also often cruel to her, as if practicing the heartlessness essential in a great revolutionary leader, and prevented her learning English for his own reasons (so that much of the evidence in the case of Lee Harvey Oswald is the record of conversations held in Russian, remembered by someone who thought in Russian). Yet Lee, who identified as a Marxist, was never a member of the Communist party, and recognised that the USSR was less successful than the USA – his core attitude was a juvenile delinquent’s hostility to any authority he was no longer capable of idealising, and a contempt for almost all other people, but as a strongly self-entitled person of progressive views he granted, in theory, everyone else a share in what he himself felt he deserved. As a social justice warrior, he was capable of admirable performative gestures, such as sitting in the black section of a segregated courtroom when arraigned in New Orleans, without seemingly ever going out of his way to perform any act of kindness for another human being in need.

There is a Jekyll and Hyde character to Lee’s politics, in which his violent acts contradict both his written statements and his progressive activism, resembling an expressionistic caricature of 20th century Marxism. Eleven years after his murder of Joseph P. Kennedy’s son, the Symbionese Liberation Army, collectivist Marxists with better childhoods and higher education than Oswald, embarked on a crime spree which included kidnapping the granddaughter of William Randolph Hearst. Their goals, motivations and grievances were, though filtered through the kaleidoscope of LSD, aligned with Oswald’s. Both Oswald and the SLA were influenced by what Elizabeth Converse, in The War of All Against All, called “the irrational Communist belief in ultimate world victory”. At its most extreme, this belief encouraged the accelerationist heresy - the belief that as Communism was inevitable, historical upheavals within Capitalist societies brought it closer, the worse the better. The accelerationist Marxist thinks like the addict who overdoses because the sooner they reach rock bottom, the sooner they can begin recovery. Thus the Communists of Weimar Germany were taught to welcome the rise of Hitler and call the liberal democrats who opposed him “fascists”, thus Posades welcomed the possibilities of nuclear war and alien invasion, thus the apocryphal Bernie bro voted for Trump. Sigmund Freud gave us the concept of Thanatos. the organism’s compulsive drive toward dissolution back into the world; Oswald’s decisions were often thanatic – his defection to the USSR, which involved cutting his left wrist and attempting to surrender his US citizenship, his assault on the Soviet bureaucracy to get both himself and Marina back to America, the time he shot at Walker, the time he stuck a pistol in his belt and said he was going to “have a look” at Richard Nixon (defused by Marina), the similarly defused planning to hijack an airliner to Cuba, the assassination itself, his refusal to consider that he might become a target afterwards.

On the morning of the 22nd of November 1963, Lee Oswald left $170 for Marina, whom he had, up to that point seldom allowed any cash at all, as well as the wedding ring he never took off, collected his rifle, and went to work at the Elm street branch of the Texas Schoolbook Depository. There, from a window on the East side of the fifth floor, he shot dead U.S. President John F. Kennedy and wounded John Connally, the Governor of Texas; later that day Lee Oswald would kill Patrolman J.D. Tippit with the cut-off Smith and Weston .38 pistol he had mail-ordered long before the rifle, but which had arrived on the same day.
Had Lee Oswald stood trial, his guilt would have been presented as a coherent narrative, and his motivations widely discussed, as he intended. Instead, he was shot dead two days later by Jack Ruby in an act almost as impulsive and last-minute as his own. Ruby’s motives are obscure – even more unstable and violent than Oswald, he was a heavy consumer of phenmetrazine, the new amphetamine also popular with The Beatles, was only 5 blocks from the assassination when it happened, and became paranoid that Jews would be blamed for the assassination, resulting in a pogrom.

The original complaint filed by the Dallas police department on Lee Oswald, around midnight on the 22nd of November, said that Lee Oswald did, "in furtherance of an international communist conspiracy, assassinate President John F. Kennedy,” but Oswald’s murder, and the lack of evidence against anyone else he knew, meant that charge would not be tested in a court of law.

The possibility that Oswald's political convictions may have played a decisive part in his shooting John F. Kennedy was down-played in the early 1960s because President Johnson and other officials did not want the assassination to become a casus belli with the Soviet Union. And to the public, this explanation, at a moment when capitalism was riding high, appeared ludicrous. Besides, for a Marxist, killing this president appeared wildly inconsistent. Kennedy was a liberal.
- Priscilla MacMillan, JFK and Oswald: The Inconvenient Truth

It may have also have mattered that no-one wanted to revisit McCarthyism. Sen Joseph McCarthy had been defeated by censure in 1954 and died in 1957; the House Unamerican Activities Committee lingered until 1975 but by 1963 was beginning to come under siege from an emerging counterculture that would become increasingly Marxist as the 60’s turned to the 1970’s. Overseas, US foreign policy and covert interventions would ensure the abduction, torture and death of many thousands of Marxists through the next few decades, yet in the USA the few leftists who knew Oswald were not persecuted, and the journals of which he said "you can see what they want you to do by reading between the lines" were not supressed.

In December of 1963 Dylan, then in the most activist stage of his folk career, was an attendee at a dinner event in New York hosted by the Emergency Civil Liberties Committee, which had awarded him its annual Tom Paine Award.

“I’ve got to admit that the man who shot President Kennedy, Lee Oswald, I don’t know exactly where — what he thought he was doing, but I got to admit honestly that I too — I saw some of myself in him. I don’t think it would have gone — I don’t think it could go that far. But I got to stand up and say I saw things that he felt, in me — not to go that far and shoot.”

The outraged crowd then expressed its hostility to the speaker.

“You can boo but booing’s got nothing to do with it. It’s a — I just a — I’ve got to tell you, man, its Bill of Rights is free speech and I just want to admit that I accept this Tom Paine Award in behalf of James Forman of the Students Non-Violent Coordinating Committee and on behalf of the people who went to Cuba.”


Fair play for Cuba.

Perhaps the first conspiracy theory about the assassination, after the statement of the Dallas PD, was held covertly – the branch of the CIA working on mind control research must logically have begun looking for evidence of a “Manchurian Candidate” brainwashing of Oswald by the KGB. The MKULTRA program, initiated in 1953, had failed to find any reliable form of brainwashing – they had been able to produce “vegetables” among their guinea pigs but not effective agents or reliable informants. The program’s budget would be reduced in 1964, but if there was the possibility that the Soviets or Cubans had succeeded in brainwashing Oswald then it could be kept alive, and perhaps vindicated. It was probably in this spirit that MKULTRA researcher Louis Jolyon West interviewed Jack Ruby in 1964, likely with the use of hypnosis and sodium pentothal. During the visit Ruby experienced a “psychotic break”, revisiting his delusion of a Kennedy-assassination inspired pogrom. Jolyon West, who killed the elephant Tusko with LSD and other drugs in 1962 and studied hippies with MKULTRA in Haight-Ashbury in late 1967, would later testify at the trial of temporary Marxist Patty Hearst in support of her defence’s brainwashing theory.

As Jolyon West was infiltrating the hippie subculture in search of the mind-control McGuffin, David Crosby was ending his career in The Byrds on stage at the Monterey Pop festival, by introducing the song He Was a Friend of Mine, a tribute to JFK, with a categorical statement of the most enduring of the JFK theories –


When President Kennedy was killed, he was not killed by one man. He was shot from a number of different directions — by different guns. The story has been suppressed, witnesses have been killed, and this is your country.

This moment marks the overground advent of progressive conspiracy theory, with its roots in Eisenhower’s Military-Industrial Complex warning, and its motivation in opposition to the Vietnam war, and more to the point, in opposition to the drafting of young American men, who naturally adapted conspiracy theory as a defence against the mass disposal of their minds and bodies by the State – analogous to the adoption of conspiracy theory defences today by those whose autonomy and future plans have been threatened by their conscription in the war against COVID-19. It was widely rumoured that LBJ, Kennedy’s Vice President and successor, under whom America had become most stickily entangled in Vietnam, had ordered the hit, but Richard Nixon and Henry Kissinger were about to show the USA, and the world, how real political conspiracies are constructed.

It was in this environment of renewed conspiracy ferment that Kerry Thornley, who had known Oswald in the US Marines and written a book inspired by his personality, The Idle Warriors, before the assassination, initiated Operation Mindfuck, with the help of Greg Hill, Robert Shea and Robert Anton Wilson. Operation Mindfuck introduced the Illuminati, through letters and ads in Playboy and other “hip” publications, to the US counterculture, with the intent of parodying the counterculture conspiracy industry and serving up an anti-stupidity vaccine with a side-order of chaos and fun. But Thornley and his accomplices underestimated the forces they were toying with, especially the human tendency to believe in malign machinations that can explain one’s own apparent impotence, dehumanise those in control, and undermine the achievements of those who have succeeded in one’s place, the same need to feel one’s weakness justified as cursed and, if one can do nothing worse, curse back that fed the belief in witchcraft in the Middle Ages and that in modern Africa.
While the Jews and Freemasons theories of the Right did not go away, they were quaintly old-fashioned and smelled strongly of old library books by the 1970’s, unable to keep up with the actual conspiracies and political and cultural developments of the Nixon-Kissinger period. The Satanic Abuse panic of the 80’s-90’s was the most successful attempt to upgrade them – arguably this succeeded, to the extent that it disrupted civil society, because it aligned with Marxist Feminist agitation against sexual exploitation; sexual Satanism was a predictable manifestation of the Patriarchy, and vice versa. Meanwhile, Hunter S Thompson had created new myths of the operation Mindfuck type, giving adrenochrome its backstory and planting a rumour about senator Eugene Muskie, the less-progressive Democratic candidate for the 1972 Presidential race, being high in ibogaine, which destroyed his candidacy. Kenny Thornley, instead of mocking the operation Mindfuck theories – which he, glimpsing the truth about Oswald, had started - began acting as if he believed in one or the other or all of them. And a young Oliver Stone, after serving in Vietnam and disapproving of the whole thing, began thinking about the assassination of JFK, who was believed posthumously to have been opposed to the War in some way.
Stone’s 1991 film JFK marks the moment when conspiracy theory passed over from the counterculture and far-right into the mainstream; it featured an impressive cast of A-list actors who presumably approved of its message of suspicion. JFK was followed by The X-Files TV series in 1993, with its telling slogan “I want to believe”. The X-Files was ironic enough, unlike Stone’s breathless film, but this didn’t inhibit the mass distribution and discussion of its ideas. Both JFK and The X-Files posit an all-powerful, yet successfully concealed Deep State for which the elected US government is window-dressing and easily removed if it objects. All around the world, this gave an easy explanation to those who resented US cultural hegemony and military power but were not the type to organise against them. It helped that it was a seemingly playful explanation, one that didn’t insist on being taken seriously enough to really test, even as it established itself in the zeitgeist.
Prior to 2001 the Deep State conspiracy theories had to co-exist with the rest of the Fortean world represented in The X-Files. UFOs, Bigfoot, spontaneous combustion, the Bermuda triangle, vampires - by the end of the 20th century, several different species of UFO-riding aliens were abducting and probing people all around the world. But after 9/11, Islamist terrorists became the aliens and monsters we watched out for and it was the US state that began abducting and probing people everywhere; reports of UFO sightings and alien abductions went into serious decline. As the plainly venal team of Bush, Cheney and Rumsfeld openly conspired to roll back freedoms and push the world into another unwinnable war, a spontaneous conspiracy of sorts arose to undermine their casus belli by suggesting that the terror attacks had been an inside job. This also meant not admitting that a Saudi Arabian NGO could get the better of the mighty USA, so it had cross-party appeal, but the list of progressive celebrities who endorsed or indulged 9/11 conspiracy theories is almost as impressive as the cast of JFK, and included Ed Asner, Spike Lee, Woody Harrelson, Rosie O’Donnell, Marion Cottillard and Graham Nash. Spreading a rumour like “Bush did 9/11” is a way of cursing the powerful, a displacement activity born of impotence and frustration, like spreading a rumour that your local feudal tyrant worships Bahomet because you are powerless to stop him taking what he wants from you. And 20 years later, Q-Anon is simply the aggregate of all the progressive counterculture conspiracy theories, including Kerry Thornley and Hunter S Thompson’s inventions, with a modified Satanic abuse element, and with the older Jews, Freemasons and Communists theories always sneaking back in.

It all began with Oswald and the trauma he induced in the USA on
November 22 1963. As NBC News anchor David Brinkley said, as he signed off that night, Kennedy’s death was “just too much, too ugly and too fast.” In 2007 Priscilla MacMillan summed up the aftermath of the assassination in a short article for World Policy Journal titled JFK and Oswald: The Inconvenient Truth.

 Oswald's act of violence indisputably ushered in an era of unease and suspicion in American life that was not there prior to the Kennedy assassination. Oswald was not responsible for all of the damage that has befallen American society since 1963, much as he would have wished to be. Some of that damage is the result of events related only tangentially to the assassination of President Kennedy. But some of the injury can, with justice, be attributed to conspiracy theorists who have gone to superhuman lengths to avoid facing the truth. They have constructed wildly-implausible scenarios, far-out, fictitious "conspirators," and have scandalously maligned the motives of Kennedy's successor, rather than take a hard look at the man who actually did it. They have, ironically, done more to poison American political life than Lee Oswald - with the most terrible of intentions - was able to do.

Kerry Thornley thought that a little light Illuminati hoaxing would make people immune to conspiracy theories, but conspiracy theories, as The X-Files and its spin-off The Lone Gunmen have proved, are immune to spoofing; Q-Anon is a spoof of spoofs, and it has outshone them all.

If the world is ready to give Marina Oswald’s story and Priscilla MacMillan’s research and analysis the same attention it once gave to Jim Garrison’s speculations, narrative will replace montage in the JFK storytelling tradition. In the near future there will be a film, or better yet a TV series, of Marina and Lee, based on the True Crime book of that name which its viewers will queue to read. In our contemporary state of disinformation hypersensitivity, it should get a more reasoned reception from the comments section than the PBS Frontline documentary series Who Was Lee Harvey Oswald did when it rescreened in 2013. We will come to understand Lee Oswald and the ideological world he inhabited, which is closer to our own than used to be the case, because the expression of low-constraint or heretical or otherwise deviationist versions of Marxist ideas is now commonplace, because glasnost revisionism, 90 Day Fiancé, RT, and Red Scare have made Marina’s voice more relatable, and because we’re now well-used to seeing violent malcontent male loners acting out the terrorist fantasies which they developed through ideological study and travel.

Imagine a counterfactual America, an alternative history wherein it has always been a well-known and accepted fact that Lee Harvey Oswald, a lone-wolf Marxist, assassinated the 35th President of the United States.

George Henderson, Auckland, Sept 2021

The killing of Oswald by Jack Ruby was the real singularity that tipped America down the path to Q-Anon, as it removed Oswald from his own story. I've called Ruby's motives "obscure" above, but obscure as they are they are not beyond all speculation. Here's what I think.

Roy Cohn, as a patriotic American Jew trying to succeed in the system, persecuted Jewish American communists because he thought they gave a bad impression of American Jews - he more-or-less framed Ethel Rosenberg and brought about her execution. This was the injustice that led to the radicalization of the young Oswald.
The Dallas newspapers had been carrying adverts against JFK that in the opinion of many at the time amounted to hate speech, and some of these were signed by Jewish Republicans (the Republican party still being the old party of tolerance for many, I suppose). Ruby was concerned about this even before the shooting, and when he heard about it panicked that the Jews would be blamed for killing JFK (as, I suppose, they had been for killing Christ) and was compelled to kill Oswald to clear their name, as a kind of sacrificial lamb for his people.
Because this involved magical thinking, and because he may have found it embarrassing in his lucid moments, Ruby gave the more innocent explanation that he had killed Oswald to spare Jackie Kennedy the pain of a trial.
Roy Cohn would go on to become the mentor of Donald Trump, and Donald Trump would go on to become the patron and beneficiary of Q-Anon.

Saturday, 20 November 2021

Selenium reduces COVID-19 risk - a back-of-the-envelope Bradford Hill analysis [originally posted 28/09/20, last updated 23/11/21]

Bradford Hill introduced a checklist for assessing the strength of epidemiological evidence for causality, which is useful in the current pandemic when nutritional factors have been insufficiently tested by experiment in favour of drugs with, so far, relatively weak effects.[1]
Remember, a long time has passed and a lot of people have died while Evidence-Based Medicine was facing the wrong way.
And asking the wrong question. "What new treatment will save more lives in the ICU?" is an important question, but one with few answers and no great ones - "What can stop people who catch SARS-CoV-2 coming to the ICU?" is a better one in a pandemic, and one that might also lead to better treatment protocols.

Selenium reduces COVID-19 mortality: A Bradford Hill analysis

1) Strength of association. Very Strong.

a) On inspection of the Hubei data, it is notable that the cure rate in Enshi city, at 36.4%, was much higher than that of other Hubei cities, where the overall cure rate was 13.1% (Supplemental Table 1); indeed, the Enshi cure rate was significantly different from that in the rest of Hubei (P < 0.0001). Enshi is renowned for its high selenium intake and status [mean ± SD: hair selenium: 3.13 ± 1.91 mg/kg for females and 2.21 ± 1.14 mg/kg for males]—compare typical levels in Hubei of 0.55 mg/kg (10)—so much so that selenium toxicity was observed there in the 1960s. Selenium intake in Enshi was reported as 550 µg/d in 2013.
Similar inspection of data from provinces outside Hubei shows that Heilongjiang Province in northeast China, a notoriously low-selenium region in which Keshan is located, had a much higher death rate, at 2.4%, than that of other provinces (0.5%; P < 0.0001). The selenium intake was recorded as only 16 µg/d in a 2018 publication, while hair selenium in the Songnen Plain of Heilongjiang was measured as only 0.26 mg/kg (Supplemental Table 2).

Finally, we found a significant association between cure rate and background selenium status in cities outside Hubei (R2 = 0.72, F test P < 0.0001; Figure 1, Supplemental Table 2).[2]

Correlation between COVID-19 cure rate in 17 cities outside Hubei, China, on 18 February, 2020 and city population selenium status (hair selenium concentration) analyzed using weighted linear regression (mean ± SD = 35.5 ± 11.1, R2 = 0.72, F test P < 0.0001). Each data point represents the cure rate, calculated as the number of cured patients divided by the number of confirmed cases, expressed as a percentage. The size of the marker is proportional to the number of cases.

b) Serum samples (n = 166) from COVID-19 patients (n = 33) were collected consecutively and analyzed for total Se by X-ray fluorescence and selenoprotein P (SELENOP) by a validated ELISA. Both biomarkers showed the expected strong correlation (r = 0.7758, p < 0.001), pointing to an insufficient Se availability for optimal selenoprotein expression. In comparison with reference data from a European cross-sectional analysis (EPIC, n = 1915), the patients showed a pronounced deficit in total serum Se (mean ± SD, 50.8 ± 15.7 vs. 84.4 ± 23.4 µg/L) and SELENOP (3.0 ± 1.4 vs. 4.3 ± 1.0 mg/L) concentrations. A Se status below the 2.5th percentile of the reference population, i.e., [Se] < 45.7 µg/L and [SELENOP] < 2.56 mg/L, was present in 43.4% and 39.2% of COVID samples, respectively.
The Se status was significantly higher in samples from surviving COVID patients as compared with non-survivors (Se; 53.3 ± 16.2 vs. 40.8 ± 8.1 µg/L, SELENOP; 3.3 ± 1.3 vs. 2.1 ± 0.9 mg/L), recovering with time in survivors while remaining low or even declining in non-survivors.[3]

c) Vitamins B1, B6, B12, D (25-hydroxyvitamin D), folate, selenium, and zinc levels were measured in 50 hospitalized patients with COVID-19. A total of 76% of the patients were vitamin D deficient and 42% were selenium deficient. No significant increase in the incidence of deficiency was found for vitamins B1, B6, and B12. folate, and zinc in patients with COVID-19. The COVID-19 group showed significantly lower vitamin D values than the healthy control group (150 people, age/sex matching). Severe vitamin D deficiency (based on 10 ng/dL) was found in 24% of the patients in the COVID-19 group and 7.3% of the control group. Among 12 patients with respiratory distress, 11 (91.7%) were deficient in at least one nutrient. However, patients without respiratory distress showed deficiency in 30/38 people (78.9%, P-value 0.425). These results suggest that a deficiency of vitamin D or selenium may decrease the immune defenses against COVID-19 and cause progression to severe disease; however, more precise and large-scale studies are needed.[18]

100% of the patients in this study with severe outcomes, including death, were selenium deficient; 75% were vitamin D deficient; none were zinc deficient.

d) In regression models, serum Se levels were inversely associated with lung damage independently of other markers of disease severity, anthropometric, biochemical, and hemostatic parameters.[23]

e) The association between soil Se level and the incidence of COVID-19 was observed in different cities of Hubei Province. The incidence of COVID-19 was more than 10 times lower in Se-enriched cities (Enshi, Shiyan, and Xiangyang) than in Se-deficient cities (Suizhou and Xiaogan).[25]

See also refs 19 and 22, discussed below.

2) Consistency - Very Strong

All epidemiological data about selenium and COVID-19 is consistent in direction and effect size. However, tests that could be done comparing COVID-19 risk in high and low selenium regions of Brazil, Scandinavia (selenium is supplemented in the food supply of Finland), and the USA would establish consistency further.

[edit 16/11/202o] - New study from South India is consistent with those from Germany, China, and South Korea:

We analysed the blood serum levels in apparently healthy (N=30) individuals and those with confirmed COVID -19 infection (N=30) in the southern part of India. Patients showed a significantly lower selenium level of 69.2 ±8.7 ng/ml than controls 79.1 ± 10.9 ng/ml, the difference was statistically significant (P=0.0003). Interestingly the controls showed a borderline level of selenium, suggesting that the level of this micronutrient is not optimum in the population studied.[19]

[edit 14/12/2020] letter from Finland in BJN compares death rate with Sweden's.

[edit 15/12/2020 deficiency of both zinc and selenium predicts COVID-19 severity in EPIC data]
"This combined deficit was observed in 0.15% of samples in the EPIC cohort of healthy subjects, in 19.7% of the samples collected from the surviving COVID-19 patients and in 50.0% of samples from the non-survivors."[22]

Statistically significant and often very strong associations between selenium intake, selenium status, and various COVID-19 outcomes have been reported from China, South Korea, Germany, South India, Russia and Europe. No null association has yet been reported.

Rigorous re-analysis of updated Chinese pandemic data published recently confirms the original observations, this time using the case-fatality rate:

A total of 147 cities each reporting over 20 cases were included in the current analysis. In these cities, 91% (14,045) of total cases and 85.8% (103) of total mortality from COVID-19 in China had been reported.
Totally, 14,045 COVID-19 cases were reported from 147 cities during 8 December 2019–13 December 2020 were included. Based on selenium content in crops, the case fatality rates (CFRs) gradually increased from 1.17% in non-selenium-deficient areas, to 1.28% in moderate-selenium-deficient areas, and further to 3.16% in severe-selenium-deficient areas (P = 0.002). Based on selenium content in topsoil, the CFRs gradually increased from 0.76% in non-selenium-deficient areas, to 1.70% in moderate-selenium-deficient areas, and further to 1.85% in severe-selenium-deficient areas (P < 0.001). The zero-inflated negative binomial regression model showed a significantly higher fatality risk in cities with severe-selenium-deficient selenium content in crops than non-selenium-deficient cities, with incidence rate ratio (IRR) of 3.88 (95% CIs: 1.21–12.52), which was further confirmed by regression fitting the association between CFR of COVID-19 and selenium content in topsoil, with the IRR of 2.38 (95% CIs: 1.14–4.98) for moderate-selenium-deficient cities and 3.06 (1.49–6.27) for severe-selenium-deficient cities

UPDATE 23/11/2021

A recent review of in-hospital selenium data shows consistent associations between lower Se and adverse outcomes in 9/10 comparisons where the population selenium level is below the optimal range of 130-150 mcg/dL. The outlier is an n=9 study (the smallest) in which length of hospital stay is the outcome and supplementation during the stay may be a confounder. In the one study where Se went over the optimal range a higher Se was found in more severe cases.[26]

3) Specificity - Strong

Selenium has much weaker or less consistent associations with other diseases, except those caused by other RNA viruses, e.g. when risk of hepatocellular cancer in viral hepatitis patients is compared with risk of osteoporosis.[4, 5]

4) Temporality - Strong

Prospective ecological comparisons are temporal by design.[2] In the German study, the temporal association between low serum selenium levels and COVID-19 symptom severity was closely tracked.[3]

Nutrients 12 02098 g003 550

5) Dose-response gradient - Very Strong

A strong, consistent dose-response is seen, even at levels where the risk of selenium toxicity exists, and despite the fact that toxic levels of soil selenium are often a legacy of industrial pollution in China.[2]

6) Plausibility - Very Strong

Reading references 2 and 3, as well as this review of the evidence written before reference 2 was published, should be persuasive.[6] See also ref 17 for antiviral effects. The effects of selenium and selenite align to support the associational results across multiple mechanisms.

7) Coherence - Very Strong

Selenium is well-studied and nothing in its story seems to contradict the idea that higher intakes will protect against COVID-19 mortality and reduce the severity of disease.
Dexamethasone, a drug which can reduce COVID-19 mortality in the ICU, enhances 1α,25-dihydroxyvitamin D3 effects by increasing vitamin D receptor transcription.[7] 
Selenium sufficiency is essential for the function of vitamin D in peripheral blood monocytes.[8] Vitamin D status also correlates with COVID-19 survival.[9]

[Edit: 20/11/20] Two conditions which are associated with selenium depletion through effects on tubular mineral resorption, sickle cell disease (aOR, 1.73; 95% CI, 1.21-2.47), and chronic kidney disease (aOR, 1.32; 95% CI, 1.29-1.36), are the comorbidities most strongly associated with COVID-19 mortality in a large US MEDICARE patient analysis.[20] Selenium status in sickle cell disease is inversely associated with markers of hemolysis, a feature of severe COVID-19 pathology.[21]

8) Experiment - Weak (Neglected)

This is an area of sufficient neglect to make you despair about medical humanity, if you know that there have been thousands of trials of potentially useless drugs for COVID-19 already. However this criteria overlaps with the next section as there are several trials of selenium supplementation in other viral diseases, and animal experiments in analogous conditions, and many mechanistic experiments that are non-specific. The interaction between SARS-CoV-2 and selenoproteins has been confirmed by experiment.[10]

UPDATE 23/11/15

This team in Wuerzburg Germany have ben steadily researching selenium in COVID-19 patients in ICU and have got to the stage of testing an intervention.
There's no control arm but we have proof of safety for 1mg sodium selenite and proof of concept in that people in whom the intervention raised SelenoP did better.
We don't yet know that this effect isn't an artifact of disease severity, but such careful work brings the needed RCT closer.

"According to intensive care unit (ICU) standard operating procedures, patients received 1.0 mg of intravenous Se daily on top of artificial nutrition, which contained various amounts of Se and Zn. Micronutrients, inflammatory cytokines, lymphocyte subsets and clinical data were extracted from the patient data management system on admission and after 10 to 14 days of treatment. Forty-six patients were screened for eligibility and 22 patients were included in the study. Twenty-one patients (95%) suffered from severe ARDS and 14 patients (64%) survived to ICU discharge. On admission, the majority of patients had low Se status biomarkers and Zn levels, along with elevated inflammatory parameters. Se supplementation significantly elevated Se (p = 0.027) and selenoprotein P levels (SELENOP; p = 0.016) to normal range. Accordingly, glutathione peroxidase 3 (GPx3) activity increased over time (p = 0.021). Se biomarkers, most notably SELENOP, were inversely correlated with CRP (rs = −0.495), PCT (rs = −0.413), IL-6 (rs = −0.429), IL-1β (rs = −0.440) and IL-10 (rs = −0.461). Positive associations were found for CD8+ T cells (rs = 0.636), NK cells (rs = 0.772), total IgG (rs = 0.493) and PaO2/FiO2 ratios (rs = 0.504). In addition, survivors tended to have higher Se levels after 10 to 14 days compared to non-survivors (p = 0.075). Sufficient Se and Zn levels may potentially be of clinical significance for an adequate immune response in critically ill patients with severe COVID-19 ARDS.[27]

In comparison to patients with a fatal outcome (n = 8), survivors (n = 14) significantly responded to supplementation with an increase in Se (p = 0.008), SELENOP (p = 0.004), GPx3 (p = 0.039) and Zn levels (p = 0.020) over the course of the ICU stay (Figure 5). Decedents had a median ICU course of 17.5 days (12–22), whereas patients with a favorable outcome were treated for significantly longer (40 days, 20–44; p = 0.025)."

There are also two tests of mixtures including selenium for COVID-19 with favourable results, the first is a survey of a clinic's patients already taking selenium, zinc, and vitamin D for  Hasimoto's thyroiditis.[28]

After adjusting for age, gender, BMI, smoking status, we found an association between the absence of supplements and the risk of hospitalization, and invasive mechanical ventilation. Patients with Hashimoto’s thyroiditis who had COVID-19 infection and who had previously taken supplements such as selenium, zinc, and vitamin D had milder clinical outcomes, or no symptoms compared to those who did not receive supplements who had a moderate or severe outcome (P <0.05)

The next is an RCT from the South Indian doctors cited earlier, of a mixed supplement supplying 40 mcg selenium (a very modest dose in this context, but not insignificant), n=100.[29]

ImmuActiveTM 500 mg capsule containing curcuminoids (100 mg), andrographolides (50 mg), resveratrol (50 mg), zinc (10 mg), selenium (40 mcg), and piperine (3 mg) or placebo was administered orally to subjects once daily after breakfast.

Results. The ordinal scale at the end of the study was significantly lower in COVID-19 patients supplemented with ImmuActive (0.57) than placebo (1.0), with a  value of 0.0043. The ordinal scale decreased by one unit within 2.35 days in ImmuActive-supplemented patients, while it took 3.36 days in placebo-supplemented patients. Days of hospitalization and time required to turn RT-PCR negative were comparatively lower in the ImmuActive arm than the placebo arm. Change in modified Jackson’s Symptom Severity Score and COVID-19 QOL were significant from screening to the end of the study in both ImmuActive and placebo arms. There were no adverse events observed during the study period.

9) Analogy - Strong

Selenium intake is protective, and selenium supplementation has been useful, in other viral illnesses.
However, the protective effect of high selenium intakes before infection in epidemiology appears stronger than the protective effect of selenium as a late intervention in disease.[6, 11]

Those are the nine canonical Bradford Hill criteria. The discussion about selenium suggests that an ad hoc 10th criteria will also be useful:

10) Risk - Weak in short-term, Well-Established in long term.

We can add the most relevant of extra questions to any given set of criteria - "strength of the alternative hypothesis" would be a good one for any lipid hypothesis.
Bradford Hill stated that some interventions are easier to justify than others.

On fair evidence we might take action on what appears to be an occupational hazard, e.g. we might change from a probably carcinogenic oil to a non-carcinogenic oil in a limited environment and without too much injustice if we are wrong. But we should need very strong evidence before we made people burn a fuel in their homes that they do not like or stop smoking the cigarettes and eating the fats and sugar that they do like. In asking for very strong evidence I would, however, repeat emphatically that this does not imply crossing every ‘t’, and swords with every critic, before we act.[1]

With nutrient intakes there is often an identifiable risk, with a J-shaped curve. With selenium the risk is selenosis, which is a condition that requires chronic high exposure (I have given myself mild selenosis with around 900mcg selenium a day and it was not a terrible condition to experience and was reversible). There could be other risks. Luckily we have an experiment that tells us where the limit is.
In a low selenium country, like New Zealand or Denmark, you don't want to take more than 200mcg of extra selenium long term.[12] Pity the low dose arms here weren't retained in the intervention.


During 6871 person-years of follow-up, 158 deaths occurred. In an intention-to-treat analysis
the hazard ratio (95% confidence interval) for all-cause mortality comparing 300 µg selenium/d to placebo was 1.62 (0.66, 3.96) after 5 years of treatment and 1.59 (1.02, 2.46) over the entire follow-up period. The 100 and 200 µg/d doses showed non-significant decreases in mortality during the intervention period that disappeared after treatment cessation. Although we lacked power for endpoints other than all-cause mortality, the effects on cancer and cardiovascular mortality appeared similar.

Howsoever that may be, taking extra selenium above 200mcg per day may yet be advised if one becomes ill with COVID-19,  but an inorganic salt of selenium like sodium selenite (which is anyhow probably safer than the selenomethionine form long-term, as I'll discuss below) is preferable, according to the selenovirus expert, Ethan Will Taylor. 
(this video link does not show in the mobile version of this post but can be reached through the web view option at the bottom)

[Edit: 1/09/20] There is also very good evidence that intravenous high dose selenite is safe in the ICU setting.

Totally 19 RCTs involving 3341 critically ill patients were carried out in which 1694 participates were in the selenium supplementation group, and 1647 in the control. The aggregated results suggested that compared with the control, intravenous selenium supplement as a single therapy could decrease the total mortality (RR = 0.86, 95% CI: 0.78–0.95, P = .002, TSA-adjusted 95% CI = 0.77–0.96, RIS = 4108, n = 3297) and may shorten the length of stay in hospital (MD −2.30, 95% CI −4.03 to −0.57, P = .009), but had no significant treatment effect on 28-days mortality (RR = 0.96, 95% CI: 0.85–1.09, P = .54) and could not shorten the length of ICU stay (MD −0.15, 95% CI −1.68 to 1.38, P = .84) in critically ill patients.[13]

This, and an earlier analysis which found less benefit, did not single out viral illnesses as a subgroup - this is only evidence for safety - but the earlier analysis did find a) slightly lower mortality in trials without an initial bolus dose, b) no increased risk in patients with renal disease.[14]

I will hypothesize briefly on selenium increasing mortality at 300 mcg/day in the Danish intervention study, a dose far too low to cause selenosis.
(The conventional signs of selenosis result from selenocysteine replacing cysteine in proteins, and the relative weakness of the Se-Se bond compared with the S-S bond.)
[Edit - hypothesis improved, 23/09/20]
The question of selenium causing insulin resistance and increasing mortality in high-dose supplements, not mirrored as far as I can see in natural high-dose populations, may have a simple explanation - supplements allow us to consume micronutrients without protein.
If you have no cysteine or methionine coming in when you take Se (either because you're not eating protein, or perhaps it can happen naturally if the Se level is high in a low-protein food and diet) then the selenocysteine formed will be incorporated into all proteins, not just the ones that require it. Including the insulin receptors, which will suffer a relative loss of function.
(similarly, though for different reasons, pyridoxine toxicity can be triggered by supplementing on a low-protein diet)

If we think that insulin resistance causes CVD, then the increased risk from (mostly) natural high Se levels is not great, see fig 5 here [15], but the intervention studies have more alarming results, and I think the competition of selenium- vs sulphur-amino acids in protein fed vs unfed states can explain this. There is next to no evidence of Se toxicity from Brazil nuts, which are high in both Se and protein.

It makes sense to me that selenomethionine, very useful as it will increase selenoprotein levels quickly if you don't have much time, should be replaced with sodium selenite for long-term coverage.

Brazil nuts are a variable quantity, a sample of nuts sold in NZ in 2008 had an average of 19 mcg per nut and increased selenoprotein levels more than selenomethionine.[16]

Plasma selenium increased by 64.2%, 61.0%, and 7.6%; plasma GPx by 8.3%, 3.4%, and -1.2%; and whole blood GPx by 13.2%, 5.3%, and 1.9% in the Brazil nut, selenomethionine, and placebo groups, respectively. Change over time at 12 wk in plasma selenium (P < 0.0001 for both groups) and plasma GPx activity in the Brazil nut (P < 0.001) and selenomethionine (P = 0.014) groups differed significantly from the placebo group but not from each other. The change in whole blood GPx activity was greater in the Brazil nut group than in the placebo (P = 0.002) and selenomethionine (P = 0.032) groups.

[Edit 02/09/20] - thanks to Mike Angell for this link; while all selenium sources are probably protective against death and ongoing harm from COVID-19, only selenite is likely to have an additional antiviral effect, and has low toxicity.[17]

A rational protocol for using selenium in prevention and treatment of COVID-19, fully consistent with the evidence discussed here, is described at the end of this paper:

All scientific work is incomplete - whether it be observational or experimental. All scientific work is liable to be upset or modified by advancing knowledge. That does not confer upon us a freedom to ignore the knowledge we already have, or to postpone the action that it appears to demand at a given time.

Austin Bradford Hill, 1965.


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